Objective
Neuroscience research tries to tease apart how brain circuits work together to give rise to behaviour, namely cognitive flexible processes, such as reinforcement learning (RL). RL requires neurons to be tuned to relevant inputs in order to maximize behavioural performance. Most of the excitatory synaptic inputs in pyramidal neurons are located in the thin dendrites where the majority of the spines are located. Thus, thin dendrites play a crucial role in synaptic integration and experience-dependent plasticity. They mediate local computations that endow single neurons with a variety of inputoutput transformations and change their information transfer. In agreement, individual dendrites have been proposed as the fundamental computational unit of neurons and the substrate for increasing the computational power of the brain. On the other hand, the neuromodulatory systems are known to be critical regulators of brain states and of adaptive responses relevant to RL. Different neuromodulators, acting through their receptors, can alter intrinsic properties of dendritic ion channels and receptors and synaptic efficacy, having a direct impact on dendritic computations. Thus, in order to understand how the brain allows to quickly improve behavioural performance during RL, it is critical that we 1) gain insight about the activity on thin dendrites, 2) to systematically understand the activity of different neuromodulatory inputs on those and 3) their impact on RL. This proposal aims at identifying how neurons change their properties during RL, by observing and manipulating the neurophysiology of behaving mice, using interdisciplinary approaches and state-of-the-art methods. The work will address several original questions: 1) what is the role of tuft dendritic activity to implement an adequate RL?; 2) what is the role of different neuromodulators in shaping the tuft dendritic activity and on RL?
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.