Noise and/or ultrafine particulate matter induced cerebral and cardiovascular damage: novel insights from experimental and epidemiological brain-heart axis biomarkers and computational models

Project Information

MARKOPOLO

Grant agreement ID: 101156161

DOI

10.3030/101156161

EC signature date 5 December 2024

Start date 1 January 2025

End date 31 December 2028

Funded under

• Health

Total cost

No data

EU contribution

€ 7 999 000,00

Coordinated by

UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (32)

The links between soil and water pollution and cardiovascular disease

Author(s): Thomas Münzel, Marin Kuntic, Jos Lelieveld, Michael Aschner, Mark J. Nieuwenhuijsen, Philip J. Landrigan, Andreas Daiber
Published in: Atherosclerosis, Issue 403, 2025, ISSN 0021-9150
Publisher: Elsevier BV
DOI: 10.1016/J.ATHEROSCLEROSIS.2025.119160

Air pollution and adverse birth outcomes: a narrative review of epidemiological and mechanistic findings

Author(s): Omar Hahad, Marin Kuntic, Sadeer Al-Kindi, Jos Lelieveld, Yafang Cheng, Volker H. Schmitt, Lukas Hobohm, Karsten Keller, Jasmin Ghaemi Kerahrodi, Sasan Faridi, Nuschin Morakkabati-Spitz, Achim Fieß, Andreas Daiber, Thomas Münzel, Michelle Bous, Sybelle Goedicke-Fritz, Michael Zemlin, Nasenien Nourkami-Tutdibi, Erol Tutdibi
Published in: Journal of Environmental Health Science and Engineering, Issue 24, 2026, ISSN 2052-336X
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S40201-026-00990-4

22. Transportation Noise and Cardiovascular Health: Evidence, Mechanisms, and Policy Imperatives

Author(s): Thomas Münzel
Published in: The Anatolian Journal of Cardiology, 2025, ISSN 2149-2263
Publisher: Kare Publishing
DOI: 10.14744/ANATOLJCARDIOL.2025.5755

Greenspaces: A natural solution to childhood malnutrition?

Author(s): Omar Hahad, Andreas Daiber
Published in: The Innovation Medicine, Issue 3, 2025, ISSN 2959-8745
Publisher: Innovation Press Co., Limited
DOI: 10.59717/J.XINN-MED.2025.100146

Gesundheitliche Auswirkungen von Waldbränden

Author(s): Thomas Münzel, Andreas Daiber
Published in: DMW - Deutsche Medizinische Wochenschrift, Issue 150, 2025, ISSN 0012-0472
Publisher: Georg Thieme Verlag KG
DOI: 10.1055/A-2542-8711

Differential inflammation, oxidative stress and cardiovascular damage markers of nano- and micro-particle exposure in mice: Implications for human disease burden

Author(s): Marin Kuntic, Ivana Kuntic, Dirk Cleppien, Andrea Pozzer, David Nußbaum, Matthias Oelze, Tristan Junglas, Lea Strohm, Henning Ubbens, Steffen Daub, Maria Teresa Bayo Jimenez, Sven Danckwardt, Thomas Berkemeier, Omar Hahad, Matthias Kohl, Sebastian Steven, Albrecht Stroh, Jos Lelieveld, Thomas Münzel, Andreas Daiber
Published in: Redox Biology, Issue 83, 2025, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/J.REDOX.2025.103644

Pharmacological treatment with a GABA(A) receptor modulator and a selective serotonin reuptake inhibitor as a mitigation strategy against aircraft noise‐induced cardiovascular and neuronal damage

Author(s): Ivana Kuntić, Marin Kuntić, Jiayin Zheng, Leonardo Nardi, Matthias Oelze, Arijan Valar, Dominika Mihaliková, Lea Strohm, Hans‐Georg Buchholz, Nicole Bausbacher, Simon Lange, Henning Ubbens, Qi Tang, Liyu Zhang, Guilherme Horta, Paul Stamm, Omar Hahad, Axel Methner, Sebastian Steven, Huige Li, Mathias Schreckenberger, Dilja Krueger‐Burg, Adrian Gericke, Michael J. Schmeisser, Thomas Münzel, Andreas Daiber
Published in: British Journal of Pharmacology, Issue 183, 2026, ISSN 0007-1188
Publisher: Wiley
DOI: 10.1111/BPH.70421

Transportation noise pollution as a cardiovascular risk factor: from epidemiological evidence to mechanistic insights

Author(s): Münzel T, Kuntic M, Molitor M, Sørensen M, Daiber A
Published in: EXCLI Journal, 2025, ISSN 1611-2156
Publisher: IfADo / EXCLI Journal (Leibniz Research Centre Dortmund)
DOI: 10.17179/EXCLI2025-9050

A comprehensive review/expert statement on environmental risk factors of cardiovascular disease

Author(s): Thomas Münzel, Mette Sørensen, Jos Lelieveld, Philip J Landrigan, Marin Kuntic, Mark Nieuwenhuijsen, Mark R Miller, Alexandra Schneider, Andreas Daiber
Published in: Cardiovascular Research, Issue 121, 2025, ISSN 0008-6363
Publisher: Oxford University Press (OUP)
DOI: 10.1093/CVR/CVAF119

Environmental Stressors and Cardiovascular Health: Acting Locally for Global Impact in a Changing World

Author(s): Thomas Münzel, Thomas Lüscher, Christopher M. Kramer, Keith Churchwell, Amam Mbakwem, Sanjay Rajagopalan
Published in: Global Heart, Issue 21, 2026, ISSN 2211-8179
Publisher: Ubiquity Press, Ltd.
DOI: 10.5334/GH.1514

Impact of noise and air pollution on the cardiovascular system through the brain–heart axis

Author(s): Arijan Valar, Jiayin Zheng, Thomas Münzel, Andreas Daiber, Marin Kuntić
Published in: Redox Experimental Medicine, Issue 2025, 2026, ISSN 2755-158X
Publisher: Bioscientifica
DOI: 10.1530/REM-25-0004

CDK12/CDK13 inhibition disrupts transcriptional elongation and replication fork progression in glioblastoma

Author(s): Silje Lier, Sara B Markusson, Anja Kocijancic, Martine Narum, Solveig O Lund, Bianka Böllering, Anuja Lipsa, Mirra L C Søegaard, Idun D Rein, Petra Santha, Preeti Jain, Anna Lång, Emma Lång, Niklas Meyer, Aparajita Dutta, Santosh Anand, Sugith B Badugu, Gaute J Nesse, Rune J Forstrøm, Arne Klungland, Ashish Anand, Steven M Pollard, Stig O Bøe, Johanne E Rinholm, Katrin B M Frauenknecht, Anna Golebiewska, Simone P Niclou, Kumar Somyajit, Mads Lerdrup, Deo P Pandey
Published in: EMBO Molecular Medicine, Issue 18, 2026, ISSN 1757-4684
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S44321-026-00393-W

Angiotensin-Converting Enzyme (ACE) Inhibitors and Statins Mitigate Negative Cardiovascular and Pulmonary Effects of Particulate Matter in a Mouse Exposure Model

Author(s): Tristan Junglas, Andreas Daiber, Ivana Kuntic, Arijan Valar, Jiayin Zheng, Matthias Oelze, Lea Strohm, Henning Ubbens, Omar Hahad, Maria Teresa Bayo Jimenez, Thomas Münzel, Marin Kuntic
Published in: Antioxidants, Issue 15, 2026, ISSN 2076-3921
Publisher: MDPI AG
DOI: 10.3390/ANTIOX15010106

The Impact of Aircraft Noise Exposure on the Efficacy of Empagliflozin Therapy in an Animal Model of Obesity

Author(s): Dominika Mihalikova, Lea Strohm, Alexander Czarnowski, Henning Ubbens, Zita Grund, Dominik Gillenkirch, Michael Molitor, Matthias Oelze, Marin Kuntic, Adrian Gericke, Philipp Lurz, Thomas Münzel, Andreas Daiber, Thomas Jansen, Paul Stamm
Published in: Diabetes & Obesity International Journal, Issue 10, 2025, ISSN 2574-7770
Publisher: Medwin Publishers
DOI: 10.23880/DOIJ-16000299

Environmental stressors and cardiovascular health: acting locally for global impact in a changing world

Author(s): Thomas Münzel, Thomas Lüscher, Christopher M Kramer, Keith Churchwell, Amam Mbakwem, Sanjay Rajagopalan
Published in: European Heart Journal, 2026, ISSN 0195-668X
Publisher: Oxford University Press (OUP)
DOI: 10.1093/EURHEARTJ/EHAF915

Cardiovascular risk posed by the exposome

Author(s): Andreas Daiber, Sanjay Rajagopalan, Marin Kuntic, Thomas Münzel
Published in: Atherosclerosis, Issue 405, 2026, ISSN 0021-9150
Publisher: Elsevier BV
DOI: 10.1016/J.ATHEROSCLEROSIS.2025.119222

Physical activity and polluted air: implications for COPD prevention and policy

Author(s): Omar Hahad, Karsten Keller, Jos Lelieveld
Published in: The Lancet Regional Health - Western Pacific, Issue 62, 2026, ISSN 2666-6065
Publisher: Elsevier BV
DOI: 10.1016/J.LANWPC.2025.101693

Environmental Stressors and Cardiovascular Health: Acting Locally for Global Impact in a Changing World: A Statement of the European Society of Cardiology, the American College of Cardiology, the American Heart Association, and the World Heart Federation

Author(s): Thomas Münzel, Thomas Lüscher, Christopher M. Kramer, Keith Churchwell, Amam Mbakwem, Sanjay Rajagopalan
Published in: Circulation, Issue 153, 2026, ISSN 0009-7322
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/CIRCULATIONAHA.125.079034

Seasonal variations in hospital admissions and case-fatality of ischemic stroke: a nationwide analysis of >4.2 million cases in Germany

Author(s): Omar Hahad, Simon-Noah Hakim-Meibodi, Seyed Hamed Rastguye Haghi, Sasan Faridi, Andreas Daiber, Alexandra Schneider, Kathrin Wolf, Nikolaos Nikolaou, Volker H. Schmitt, Philipp Lurz, Christine Espinola-Klein, Yafang Cheng, Andrea Pozzer, Jos Lelieveld, Thomas Münzel, Daniel Wollschläger, Lukas Hobohm, Karsten Keller
Published in: Frontiers in Epidemiology, Issue 6, 2026, ISSN 2674-1199
Publisher: Frontiers Media SA
DOI: 10.3389/FEPID.2026.1750089

From heavy smog to healthy hearts: China’s clean air act as a blueprint for cardiovascular disease prevention

Author(s): Marin Kuntic, Jos Lelieveld, Thomas Münzel
Published in: European Journal of Preventive Cardiology, 2026, ISSN 2047-4873
Publisher: Oxford University Press (OUP)
DOI: 10.1093/EURJPC/ZWAG157

Ambient air and noise pollution effect on cardiovascular health risk and lifestyle intervention to attenuate it: study protocol for a randomized clinical trial

Author(s): Regina Grazuleviciene, Sandra Andrusaityte, Audrius Dedele, Ausra Kapustinskaite
Published in: Frontiers in Public Health, Issue 14, 2026, ISSN 2296-2565
Publisher: Frontiers Media SA
DOI: 10.3389/FPUBH.2026.1747963

The impact of environmental pollution and climate change on hypertension: a position paper by the European Society of Hypertension (ESH) Working Group on Environment in Hypertension

Author(s): Marek Rajzer, Wiktoria Wojciechowska, Andrzej Januszewicz, Yu-Ling Yu, Ji-Guang Wang, Omar Hahad, Andreas Daiber, Manuel Spitschan, Philippe van de Borne, Bojan Jelaković, Ana Jelaković, De-Wei An, Xiao-Fei Ye, Grzegorz K Jakubiak, Michel Burnier, Alexandre Persu, Thomas Weber, Tomasz J Guzik, Reinhold Kreutz, Thomas Münzel, Jan A Staessen
Published in: Cardiovascular Research, Issue 122, 2026, ISSN 0008-6363
Publisher: Oxford University Press (OUP)
DOI: 10.1093/CVR/CVAG061

Physical activity and air pollution: context matters for cardiovascular health

Author(s): Omar Hahad, Sadeer Al-Kindi
Published in: The Lancet Regional Health - Western Pacific, Issue 60, 2025, ISSN 2666-6065
Publisher: Elsevier BV
DOI: 10.1016/J.LANWPC.2025.101612

From noise to heart disease: European Environment Agency sounds the alarm for Europe 2025

Author(s): Thomas Münzel, Eulalia Peris, Mette Sørensen
Published in: European Heart Journal, Issue 47, 2026, ISSN 0195-668X
Publisher: Oxford University Press (OUP)
DOI: 10.1093/EURHEARTJ/EHAF1072

Airborne Ultrafine Particles: Real-life Exposure Patterns, Epidemiological Evidence and Regulatory Responses in Switzerland and Beyond

Author(s): Marloes Eeftens, Eric P. Twomey, Fiona Streit, Martin Röösli
Published in: CHIMIA, Issue 80, 2026, ISSN 2673-2424
Publisher: Swiss Chemical Society
DOI: 10.2533/CHIMIA.2026.64

Environmental Hypertensionology and the Mosaic Theory of Hypertension

Author(s): Sanjay Rajagopalan, Robert D. Brook, Thomas Münzel
Published in: Hypertension, Issue 82, 2025, ISSN 0194-911X
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/HYPERTENSIONAHA.124.18733

Transportation noise and the cardiometabolic risk

Author(s): Thomas Münzel, Marin Kuntic, Andreas Daiber, Mette Sørensen
Published in: Atherosclerosis, Issue 403, 2025, ISSN 0021-9150
Publisher: Elsevier BV
DOI: 10.1016/J.ATHEROSCLEROSIS.2025.119148

Circadian rhythms in cardiovascular disease

Author(s): Ilse R Kelters, Yvonne Koop, Martin E Young, Andreas Daiber, Linda W van Laake
Published in: European Heart Journal, Issue 46, 2025, ISSN 0195-668X
Publisher: Oxford University Press (OUP)
DOI: 10.1093/EURHEARTJ/EHAF367

A randomized, double-blind, crossover study of acute low-level night-time road traffic noise: effects on vascular function, sleep, and proteomic signatures in healthy adults

Author(s): Omar Hahad, Patrick Foos, Jonas Hübner, Christina Große-Dresselhaus, Frank P Schmidt, Mir Abolfazl Ostad, Marin Kuntic, Lukas Hobohm, Karsten Keller, Volker H Schmitt, Thomas Köck, Philipp Wild, Irene Schmidtmann, Mette Sørensen, Martin Röösli, Paul Stamm, Alexander von Kriegsheim, Johannes Herzog, Philipp Lurz, Andreas Daiber, Thomas Münzel
Published in: Cardiovascular Research, Issue 122, 2026, ISSN 0008-6363
Publisher: Oxford University Press (OUP)
DOI: 10.1093/CVR/CVAG028

Environmental Stressors and Cardiovascular Health: Acting Locally for Global Impact in a Changing World

Author(s): Thomas Münzel, Thomas Lüscher, Christopher M. Kramer, Keith Churchwell, Amam Mbakwem, Sanjay Rajagopalan
Published in: JACC, Issue 87, 2026, ISSN 0735-1097
Publisher: Elsevier BV
DOI: 10.1016/J.JACC.2026.01.015

Global high-resolution ultrafine particle number concentrations through data fusion with machine learning

Author(s): Pantelis Georgiades, Matthias Kohl, Mihalis A. Nicolaou, Theodoros Christoudias, Andrea Pozzer, Constantine Dovrolis, Jos Lelieveld
Published in: Scientific Data, Issue 12, 2025, ISSN 2052-4463
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41597-025-06055-9

Underestimated Environmental Risks for People with Arterial Hypertension - A Narrative Review of Issues that National Guidelines Should Consider

Author(s): Katarina Paunović, Snežana Pejić, Ana Šuša, Ana Todorović, Dunja Drakulić, Katarina Bobić, Katarina Đurđević, Branko Jakovljević
Published in: Noise and Health, Issue 28, 2026, ISSN 1463-1741
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.4103/NAH.NAH_241_25