Project description
Advancing therapeutic potential of extracellular vesicles
Extracellular vesicles (EVs) are vital in regulating both healthy and diseased states, including cancer and regenerative conditions. However, the therapeutic market for EVs remains underdeveloped, primarily due to limitations in production methods. Current technologies lack the ability to produce high yields efficiently and struggle to adapt to different types of producer cells. This adaptability is critical, as the therapeutic effectiveness of EVs is closely tied to the condition of their parent cells. The ERC-funded EVoid project seeks to overcome these challenges by integrating precise control of cell configurations with high-throughput EV production, creating a streamlined system that enhances EV-based therapies.
Objective
Extracellular vesicles (EVs) have emerged as pivotal regulators of both physiological homeostasis and pathological conditions, including cancer and regenerative diseases, and have recently been pinpointed as central effectors in the therapeutic capabilities of their parent cells. Nevertheless, the therapeutic market of EVs still has significant potential for further development. Specifically, EV production methods that deliver robust, scalable and high-yield productions, if possible with the minimum cell material, are still unattainable. Besides, existing technologies are not adequately versatile to accommodate different types of producer cells, which is of particular relevance, given that the biological makeup of the EVs, and in turn their therapeutic potential, strongly depend on the state of the parental cells when stimulated. Here, we aim to integrate tight control of produced cells configuration with high-throughput production of EVs in a streamlined system.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-POC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.