Project description
Innovative Antibody-Drug Conjugate for macrophage depletion in tumours
Tumour-Associated Macrophages (TAMs) within the Tumour Microenvironment (TME) play a significant role in tumour progression and immune evasion, necessitating the development of novel treatments. The ERC-funded TAM-AdaCT project seeks to pioneer an Antibody-Drug Conjugate (ADC) specifically for macrophage depletion within the TME. Concentrating on breast cancer and solid tumours, the proposed ADC will directly target these macrophages, effectively depleting them and fostering a more conducive environment for tumour eradication. The project aims to produce optimised ADCs capable of precisely targeting and depleting TAMs within the TME. It will validate ACC efficacy in preclinical models, assess its potential for human application, analyse its intellectual property landscape, and devise a strategy for commercial development.
Objective
"The project is focused on the development of a groundbreaking Antibody-Drug Conjugate (ADC) specifically designed for macrophage depletion in the Tumor Microenvironment (TME). With a primary focus on breast cancer and solid tumors, this initiative represents a paradigm shift in cancer therapeutics.
The presence of Tumor-Associated Macrophages (TAMs) in the TME has been identified as a significant factor in tumor progression and immune evasion. Our proposed ADC will directly target these macrophages, effectively depleting them and thereby creating a more favorable environment for tumor eradication.
The primary objectives of this project are as follows:
1. To synthesise and optimise ADCs for specific targeting and depletion of TAMs in the TME.
2. To demonstrate the efficacy of the ADC in preclinical models, establishing its potential for human application.
3. To perform a thorough ""freedom to operate"" analysis, ensuring that the ADC technology does not infringe upon existing intellectual property rights.
4. To establish a detailed plan for the commercial development of this ADC, outlining steps for regulatory approval, manufacturing scalability, and market entry.
By achieving these objectives, we aim to propel this project from the conceptual stage to a viable, commercialisable medical solution. The successful implementation of this ADC has the potential to revolutionise cancer treatment, offering a targeted approach that could significantly improve patient outcomes. The support of ERC Proof of Concept Grant will be pivotal in transitioning this transformative technology from the laboratory to the marketplace, ultimately changing the landscape of cancer therapeutics.
The strategic positioning of Zelula Biopharma (Host Institution) as a spin-off of CIC bioGUNE adds substantial value to this project, leveraging a unique blend of resources, academic research excellence and entrepreneurial agility to accelerate the transition from lab to market."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-POC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
20014 SAN SEBASTIAN
Spain
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.