TRIAD: Enhancing Synergism on Telomere Function in Health and Disease

Project Information

TRIAD

Grant agreement ID: 101158508

DOI

10.3030/101158508

EC signature date 8 April 2024

Start date 1 May 2024

End date 30 April 2027

Funded under

• Widening participation and spreading excellence

Total cost

€ 1 200 000,00

EU contribution

€ 1 200 000,00

Coordinated by

PANEPISTIMIO KRITIS
Greece

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

Targeting DNA damage in ageing: towards supercharging DNA repair

Author(s): Arturo Bujarrabal-Dueso, George A. Garinis, Paul D. Robbins, Jan Vijg, Björn Schumacher
Published in: Nature Reviews Drug Discovery, 2025, ISSN 1474-1776
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41573-025-01212-6

Mechanism of BCDX2-mediated RAD51 nucleation on short ssDNA stretches and fork DNA

Author(s): Masaki Akita; Paul Girvan; Mario Spirek; Jiri Novacek; David Rueda; Zbynek Prokop; Lumir Krejci
Published in: Nucleic Acids Research, 2024, ISSN 1362-4962
Publisher: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAE770

Looping forward: exploring R‐loop processing and therapeutic potential

Author(s): Kalliopi Stratigi, Athanasios Siametis, George A. Garinis
Published in: FEBS Letters, Issue 599, 2025, ISSN 0014-5793
Publisher: Wiley
DOI: 10.1002/1873-3468.14947

Telomeric Repeat-Containing RNA: Biogenesis, Regulation, and Functions

Author(s): Patricia L. Abreu, Valentina Riva, Luca Zardoni, Claus M. Azzalin
Published in: Cold Spring Harbor Perspectives in Biology, 2025, ISSN 1943-0264
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/CSHPERSPECT.A041683

TRF1 relies on fork reversal to prevent fragility at human telomeres

Author(s): Mélina Vaurs, Eloïse Claude, Elia Zanella, Joana Rodrigues, Joe Nassour, Jan Karlseder, Claus M. Azzalin, Ylli Doksani, Anabelle Decottignies
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61828-5

From Genome to Geroscience: How DNA Damage Shapes Systemic Decline

Author(s): Athanasios Siametis, George A. Garinis
Published in: BioEssays, 2025, ISSN 0265-9247
Publisher: Wiley
DOI: 10.1002/BIES.70051

RECQ4-MUS81 interaction contributes to telomere maintenance with implications to Rothmund-Thomson syndrome

Author(s): Raghib Ashraf, Hana Polasek-Sedlackova, Victoria Marini, Jana Prochazkova, Zdenka Hasanova, Magdalena Zacpalova, Michala Boudova, Lumir Krejci
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-56518-1

Lessons from Portugal on effects of cutting research funding

Author(s): Marc Veldhoen, João T. Barata, Luisa M. Figueiredo, Claus M. Azzalin
Published in: Nature, Issue 639, 2025, ISSN 0028-0836
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/D41586-025-00928-0

Discovery of new inhibitors of nuclease MRE11

Author(s): Fedor Nikulenkov, Benoit Carbain, Raktim Biswas, Stepan Havel, Jana Prochazkova, Alexandra Sisakova, Magdalena Zacpalova, Melita Chavdarova, Victoria Marini, Vit Vsiansky, Veronika Weisova, Kristina Slavikova, Dhanraj Biradar, Prashant Khirsariya, Marco Vitek, David Sedlak, Petr Bartunek, Lukas Daniel, Jan Brezovsky, Jiri Damborsky, Kamil Paruch, Lumir Krejci
Published in: European Journal of Medicinal Chemistry, Issue 285, 2025, ISSN 0223-5234
Publisher: Elsevier BV
DOI: 10.1016/J.EJMECH.2024.117226

Loss of genome maintenance is linked to mTOR complex 1 signaling and accelerates podocyte damage

Author(s): Fabian Braun, Amrei M. Mandel, Linda Blomberg, Milagros N. Wong, Georgia Chatzinikolaou, David H. Meyer, Anna Reinelt, Viji Nair, Roman Akbar-Haase, Phillip J. McCown, Fabian Haas, He Chen, Mahdieh Rahmatollahi, Damian Fermin, Robin Ebbestad, Gisela G. Slaats, Tillmann Bork, Christoph Schell, Sybille Koehler, Paul T. Brinkkoetter, Maja T. Lindenmeyer, Clemens D. Cohen, Martin Kann, David Unnersjö-Jess, Wilhelm Bloch, Matthew G. Sampson, Martijn E.T. Dollé, Victor G. Puelles, Matthias Kretzler, George A. Garinis, Tobias B. Huber, Bernhard Schermer, Thomas Benzing, Björn Schumacher, Christine E. Kurschat
Published in: JCI Insight, Issue 10, 2025, ISSN 2379-3708
Publisher: American Society for Clinical Investigation
DOI: 10.1172/JCI.INSIGHT.172370

Dbl2 interacts with helicases and an endonuclease to maintain the integrity of repetitive regions

Author(s): Anetta Bakosova, Lubos Cipak, Nina Mayerova, Kamil Krol, Zsigmond Benko, Alexandra Pitelova, Peter Kolesar, Dominika Piatrova, Maria Smondrkova, Anna Maresova, Lucia Molnarova, Ingrid Cipakova, Veronika Altmannova, Jana Bellova, Peter Barath, Martin Prevorovsky, Jan Palecek, Lumir Krejci, Juraj Gregan, Adrianna Skoneczna, Silvia Bagelova Polakova
Published in: Scientific Reports, Issue 15, 2025, ISSN 2045-2322
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-08626-7

The epitranscriptome: reshaping the DNA damage response

Author(s): Vivian Kalamara, George A. Garinis
Published in: Trends in Cell Biology, Issue 35, 2025, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/J.TCB.2024.06.008

Reading the DNA of telomeres

Author(s): Shamayita Roy, Claus M Azzalin
Published in: eLife, Issue 14, 2025, ISSN 2050-084X
Publisher: eLife Sciences Publications, Ltd
DOI: 10.7554/ELIFE.107648