Synergy for Healthy Longevity

Información del proyecto

SynHealth

Identificador del acuerdo de subvención: 101159018

DOI

10.3030/101159018

Fecha de la firma de la CE 1 Marzo 2024

Fecha de inicio 1 Marzo 2024

Fecha de finalización 28 Febrero 2027

Financiado con arreglo a

• Widening participation and spreading excellence

Coste total

€ 1 217 125,00

Aportación de la UE

€ 1 217 125,00

Coordinado por

GENOS DOO ZA VJESTACENJE I ANALIZU
Croatia

Periodic Reporting for period 1 - SynHealth (Synergy for Healthy Longevity)

Período documentado: 2024-03-01 hasta 2025-05-31

Resumen del contexto y de los objetivos generales del proyecto

The rapid increase in global life expectancy presents both a triumph of modern medicine and a significant societal challenge. As people live longer, ensuring these extended years are healthy and productive requires a concerted effort to prevent and manage age-related diseases and enhance overall well-being. This is the central challenge that the SynHealth project aims to address. "Synergy for Healthy Longevity" is a groundbreaking European-funded initiative dedicated to unlocking the secrets of healthy ageing and translating this knowledge into tangible benefits for citizens. Our primary objective is to bridge existing gaps in research, healthcare, and innovation by fostering unprecedented collaboration across diverse fields and stakeholders. By synergising expertise from various disciplines, including biological sciences, medical research, public health, social sciences, and cutting-edge digital technologies like Artificial Intelligence and big data analytics, we can develop holistic and personalised approaches to promoting healthy longevity.

Glycan biomarkers hold great promise for earlier disease detection and personalised healthcare, but their clinical implementation remains limited. The SynHealth project aims to valorise glycan biomarker research and prepare it for ERDF funding, enabling implementation in two Croatian and one Slovenian region. This will boost innovation capacity and competitiveness in less-developed areas.

Key objectives include:
SO1: Develop an AI-based tool to scale GlycanAge personalised counselling and support healthcare professionals, with pilot validation.
SO2: Prepare a clinical study for glycan biomarkers, including a regulatory roadmap and collaborations with clinical centres.
SO3: Demonstrate the use of glycan biomarkers in real-life settings through pilot projects and establish regional healthcare partnerships.
SO4: Strengthen innovation and IP management capacities through workshops and support future ERDF proposals.
SO5: Maximise project impact through targeted communication, dissemination, and EU-level networking to engage key stakeholders.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

During the reporting period, progress was made across key deliverables and milestones. We submitted the Valorization Studies (D2.1) and the Regulatory Road to Market Plan (D2.2) by month 15, outlining market potential and regulatory needs. The Workshop on Innovation, Innovation Management, and Knowledge Transfer (D5.1) in month 15 supported consortium-wide knowledge exchange. The Dissemination and Exploitation Plan (D6.1) defined communication activities to raise awareness and increase impact. Data handling was addressed early with the Data Management Plan (D7.1) in month 6, ensuring compliance with standards. The Kick-off Event (M1) in month 2 launched the project under WP7, while the Project Website (M2), live by month 3 (WP6), provides a key platform for outreach. The explainable prediction model for extracting scientific summaries (M3, WP1) progressed toward completion by month 15. A Preparatory Workshop with ERDF authorities (M4, WP4) was held in month 12 to ensure alignment with funding rules and best practices. These outcomes reflect strong progress and position the project well for the next phases.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

SynHealth is preparing glycan biomarkers for personalised preventive healthcare by developing an AI-based counselling tool (GlycanAge), drafting a clinical study protocol, and launching pilot studies in Croatia and Slovenia. The project has also strengthened regional innovation ecosystems and enhanced collaboration across research, clinical, and industry sectors.
The expected impact includes earlier detection of disease risk, more personalised care, and better health system efficiency. The project also contributes to smart specialisation and builds capacity in less-developed regions through targeted training and knowledge transfer.
To ensure further uptake and sustainability of SynHealth results, several key needs have been identified:
First, the finalisation of the clinical validation and the regulatory roadmap is essential to enable the transition of glycan biomarkers from research to routine clinical use. This includes aligning study protocols with regulatory expectations and ensuring readiness for CE-IVDR compliance.
Secondly, broader demonstration in real-world healthcare settings is needed to confirm usability, scalability, and value of the developed tools and biomarkers in diverse clinical environments.
Access to funding—particularly through the European Regional Development Fund (ERDF) and national programmes—is crucial to support the scale-up and regional implementation of the solutions developed within the project.
Protection of intellectual property rights (IPR) and access to commercialisation expertise will ensure the long-term sustainability and market readiness of key innovations, such as the AI-based counselling tool.
Establishing strong partnerships with industry and engaging potential investors will be critical to support technology transfer, product development, and market access.
Moreover, alignment with CE-IVDR and national regulatory frameworks is required to ensure legal compliance and facilitate healthcare system integration.
Finally, continued international networking and visibility will help position SynHealth within the European personalised medicine ecosystem and promote cross-border collaboration, scalability, and policy impact.