Objetivo
The search for a therapeutic intervention that can lead to HIV remission or cure is a global priority of the HIV field. HIV-specific antibodies have the potential to alter the clinical course of infection and enhance antiviral immune responses. In addition, we have recently demonstrated that antibody-based HIV immunotherapy results in higher-than-average cases of durable HIV remission in the absence of antiretroviral medication. Moreover, passive administration of HIV-specific antibodies was associated with reductions in the size of the replication-competent HIV reservoir which is the major barrier towards a cure for HIV. While these results highlight the exceptional potential of HIV immunotherapy, it is critical to understand the underlying mechanisms responsible for higher rates of HIV remission and antibody-mediated changes in the reservoir. Therefore, we will identify individuals with long-term HIV remission from clinical antibody-immunotherapy trials before comprehensively characterizing host immune responses, host-viral gene expression and the HIV latent reservoir. By combining highly valuable clinical samples with novel strategies for the characterization of viral immunity and persistence, we aim to establish a relationship between antibody-based HIV immunotherapy, host immunological factors, adaptive immune responses, and the nature of the viral reservoir with the overarching goal of developing clinical interventions for long-term, drug-free HIV remission or cure.
Ámbito científico (EuroSciVoc)
CORDIS clasifica los proyectos con EuroSciVoc, una taxonomía plurilingüe de ámbitos científicos, mediante un proceso semiautomático basado en técnicas de procesamiento del lenguaje natural.
CORDIS clasifica los proyectos con EuroSciVoc, una taxonomía plurilingüe de ámbitos científicos, mediante un proceso semiautomático basado en técnicas de procesamiento del lenguaje natural.
- ciencias médicas y de la saludmedicina básicafarmacología y farmaciamedicamento
- ciencias médicas y de la saludciencias de la saludenfermedad infecciosavirus de ARNVIH
- ciencias médicas y de la saludmedicina básicainmunologíainmunoterapia
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Programa(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Régimen de financiación
HORIZON-ERC - HORIZON ERC GrantsInstitución de acogida
10117 Berlin
Alemania