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A Novel ‘Radiotherapy from Within’ Platform Technology for the Targeted Treatment of Solid Tumours Called ‘BAT-90’

Project description

Guided percutaneous radiation therapy precisely and effectively targets solid tumours

Radiation therapy has improved tremendously over the last decades to include external beam radiotherapy, brachytherapy, proton beam radiotherapy, trans-arterial radio-embolisation, and microwave ablation. Despite their benefits, these treatments have certain accessibility and off-target side-effect limitations. With the support of the European Innovation Council, the Italian therapeutics company BetaGlue Technologies aims to overcome these challenges by accelerating commercialisation of its revolutionary personalised and cost-effective anti-tumoural platform technology called BAT-90. The EIC-funded BAT-90 project has already demonstrated safety and preliminary effectiveness in human clinical studies. The project will support further efforts to make guided percutaneous administration of BAT-90 an available radiotherapeutic treatment option for difficult-to-treat solid tumours including types of hepatocellular carcinoma and pancreatic cancer.

Objective

"BetaGlue is developing an innovative ""radiotherapy from within"", personalized and cost-effective anti-tumoural platform technology called BAT-90. BAT-90 maximises the therapeutic index of loco-regional treatment by eliminating off-target radiation dose in a simple and easy to use product. The product aims to provide a radiotherapeutic treatment option for a range of solid tumour types including: unresectable hepatocellular carcinoma (HCC) and locally advanced and borderline resectable pancreatic cancer (PDAC) patients, where in the first-line setting, there exists a major unmet clinical need. Through the percutaneous administration of BAT-90 under radiological guidance (usually ultrasound) BAT-90 overcomes the accessibility and off-target side effect limitations of external beam radiotherapy, forms of brachytherapy, proton beam radiotherapy trans-arterial radio-embolisation and microwave ablation. BAT-90 has already demonstrated safety and preliminary effectiveness in first-in-human clinical studies."

Fields of science (EuroSciVoc)

Keywords

Programme(s)

Topic(s)

Funding Scheme

HORIZON-EIC-ACC-BF - HORIZON EIC Accelerator Blended Finance

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Call for proposal

(opens in new window) HORIZON-EIC-2023-ACCELERATOR-01

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Coordinator

BETAGLUE THERAPEUTICS SPA
Net EU contribution
€ 2 499 999,00
Address
VIA DELLA MOSCOVA 3
20121 Milano
Italy
SME
Yes
Region
Nord-Ovest Lombardia Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Total cost
€ 7 135 824,00