Project description
Decoding the blueprint of multicellular development
Understanding how complex multicellular organisms develop into their final forms remains one of biology’s greatest challenges. Despite advances, scientists still struggle to predict and re-engineer development with precision. This knowledge is vital for fundamental biology and advancements in regenerative medicine and agriculture. While development relies on symmetry-breaking events, from molecular asymmetry within cells to large-scale tissue patterning, the processes remain elusive. In this context, the ERC-funded RESYDE project seeks to unravel these mysteries by integrating diverse data into a virtual, dynamic cellular template. Using Arabidopsis flowers as a model, researchers will combine live imaging, multi-omics, and predictive modelling to decode symmetry-breaking events, thereby laying the groundwork for re-engineering biological development by design.
Objective
Scientists have long sought to understand how complex multicellular organisms generate their final form. Yet despite considerable progress, demonstrating predictive knowledge sufficient to re-engineer development according to design, remains a grand challenge. Addressing this challenge is not only fundamentally important, but also critical to the future of regenerative medicine and agriculture. Development depends on coordinated symmetry breaking events resulting from diverse mechanisms, ranging from the asymmetric localisation of molecules and stochastic processes within cells to the formation of morphogen gradients across a tissue. A mechanistic understanding of complex patterning processes therefore requires gaining knowledge on the molecular basis of multiple types of symmetry breaking events occurring at different scales. RESYDE will address this challenge by integrating information from diverse approaches into a virtual, dynamic cellular template. Predictive modelling will then be used to explain symmetry breaking at different scales sufficient to re-engineer the system by design. We will use the Arabidopsis flower as a model system and apply an interdisciplinary approach that utilises fine-scale perturbation techniques together with in vivo live-imaging of key regulators along with spatially mapped multi omics data, hormonal gradients and tissue mechanics to monitor responses at multiple scales. To leverage these data we will establish a 4D virtual cell template together with multiscale models to generate and simulate hypotheses in silico on the precise molecular origins of symmetry breaking events within the flower. We will apply our knowledge using a re-engineering approach to alter multiple floral symmetry breaking processes to better understand evolutionary floral architectural changes. Ultimately, RESYDE will provide a fundamental step change in our understanding of concerted symmetry breaking events across scales in complex multicellular contexts.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences agriculture, forestry, and fisheries agriculture
- natural sciences computer and information sciences software software applications simulation software
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-SYG - HORIZON ERC Synergy Grants
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2024-SyG
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10117 Berlin
Germany
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