Project description
Eradicating minimal residual disease in leukaemia
Residual therapy-resistant cancer cells, called minimal residual disease (MRD) pose a major challenge in leukaemia treatment. MRD is responsible for relapse, which is difficult to treat and the cause of the low survival rates of patients. Currently, MRD detection is crucial for predicting the risk of a relapse. However, mechanisms of MRD development are currently unknown, making it difficult to design treatment strategies to prevent relapse. With the support of the Marie Skłodowska-Curie Actions programme, the MIRACLE project will train a new generation of researchers to understand MRD persistence mechanisms and develop effective, less toxic treatments. The project will combine cutting-edge technologies and advanced data analysis to equip researchers with the skills for creating new therapeutics and improving leukaemia treatment outcomes.
Objective
An estimated 300,000 new cases of leukemia are diagnosed each year globally. The most common form of acute leukemia is acute myeloid leukemia (AML), which is generally a disease of the elderly, while acute lymphoid leukemia (ALL) is most prevalent in children. The biggest problem associated with leukemia treatment is persistence of residual therapy-resistant cancer cells, called minimal residual disease (MRD). MRD can latently persist in the patient for many months, and in response to unknown signals can reawaken and initiate a relapse, which is difficult to treat and responsible for the low survival rates of patients. Currently, knowledge on mechanisms responsible for persistence of MRD and initiation of leukemia relapse is lacking, making development of therapeutics eradicating MRD difficult and hampering improvement of patient cure rates. MIRACLE aims at eradication of MRD and development of clinically efficient treatment strategies that can deliver long-lasting benefit to patients by training a new generation of researchers.
MIRACLE will elucidate the leukemia MRD landscape by integrating the knowledge on mechanisms driving persistence of MRD from different angles, and by the subsequent design of efficient and less toxic, novel targeted combination therapy with increased capacity to induce deep responses in patients. With its multidisciplinary team of scientists from academia and industry MIRACLE aims to educate a new generation of researchers optimally equipped to advance and accelerate development of novel therapeutics directed to MRD, and to progress effective treatments to the clinic. The researchers within MIRACLE will be trained to obtain a unique combination of skills in innovative high-tech technologies, advanced data analysis tools and artificial intelligence, organ-on-chip MRD models, and drug and immunotherapy testing, and will come with innovative ideas to advance future leukemia treatment by integration of several disciplines and data sources.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been validated by the project's team.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been validated by the project's team.
- natural sciences computer and information sciences artificial intelligence
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance
- medical and health sciences basic medicine immunology immunotherapy
- engineering and technology other engineering and technologies microtechnology organ on a chip
- medical and health sciences clinical medicine oncology leukemia
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-DN-01
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1081 HV Amsterdam
Netherlands
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Participants (8)
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116 36 Praha 1
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2342 DH Oegstgeest
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9052 ZWIJNAARDE - GENT
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75654 PARIS
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41004 Sevilla
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20132 Milano
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60323 Frankfurt Am Main
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80539 MUNCHEN
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Partners (13)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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2719EA Zoetermeer
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42002 Soria
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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1217 CM Hilversum
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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2517 ES Den Haag
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3290 Diest
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1068 PM Amsterdam
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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3503 RD Utrecht
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1410 Waterloo
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1081 HV Amsterdam
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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3000 Leuven
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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20132 Milano
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
CB2 1TN CAMBRIDGE
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
60596 Frankfurt Am Main
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.