Project description
Advancing immunotherapy for metastatic cancer
The interplay between tumour cells and the host immune system is complex and involves a dynamic balance between immune-mediated tumour suppression and tumour-driven immune evasion. Understanding these local interactions at an early timepoint of metastatic invasion is crucial for the development of immunotherapies and for targeting advanced metastatic disease. With the support of the Marie Skłodowska-Curie Actions programme, the Mac4Me project will investigate tumour cell-immune host interactions at metastatic sites through a multidisciplinary approach. The consortium will develop innovative organ-on-chip systems to model early metastasis in brain, bone, and liver and integrate preclinical data with clinical findings to identify new immune targets with AI. Moreover, the project will train societal and basic science doctorate candidates in participatory science.
Objective
Immunotherapies promise to be the major break-through in the treatment of metastatic cancer, but effectiveness is limited to few cancer types. Metastatic neuroblastoma, breast and prostate cancer, affecting approximately 300,000 EU-27 inhabitants of all age groups in 2020, respond not or very poorly to current immunotherapies. To establish more effective immunotherapies, we need to better understand the specific tumour cell-immune host interactions at the metastatic site.
The Mac4Me Doctoral Network adopts an innovative, multidisciplinary and cross-sectional approach, with a unique and dedicated research training programme to equip young researchers with scientific knowledge and transferable skills that are essential for today’s great demand in both academic and non-academic sectors.
Mac4Me aims to understand the tumour cell-immune host interactions at the metastatic site. with an in-depth molecular and mechanistic understanding of the immune and matrix changes induced by tumour cells. We will use innovative animal-free organ-on-chip systems, that recapitulate early metastasis formation of brain, bone and liver. The retrieved knowledge from the preclinical models will be integrated in data from established clinical metastases and AI machine learning algorithms will be applied to identify new immune targets. Mac4Me will align with patients and the general public from the very beginning thereby bringing societal expectations and patient needs into the centre of the project to pave the way for new standards for shared decision making and acceptable health care solutions.
Mac4Me will prepare a next generation of young scientists to start their own career as independent researchers being equipped with scientific knowledge and personal skills and integrating participatory science as a starting point to address the societal demand for more effective treatment solutions for incurable metastatic disease, such as neuroblastoma, breast and prostate cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- medical and health sciencesclinical medicineoncologyprostate cancer
- medical and health sciencesbasic medicineimmunologyimmunotherapy
- engineering and technologyother engineering and technologiesmicrotechnologyorgan on a chip
- natural sciencescomputer and information sciencesartificial intelligencemachine learning
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Keywords
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksCoordinator
3015 GD Rotterdam
Netherlands
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Participants (10)
60323 Frankfurt Am Main
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2 Dublin
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2628 CN Delft
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01069 Dresden
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16121 Genova
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
00014 HELSINGIN YLIOPISTO
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33100 Tampere
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
0450 Oslo
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3062 PA Rotterdam
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08002 Barcelona
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Partners (14)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
3012 Bern
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
2010 Sydney Nsw
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
20133 Milano
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
20520 Turku
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
25170 Placey
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
4 Dublin
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
33100 Tampere
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
20126 Milano
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
NG7 2TU Nottingham
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
2000 Antwerpen
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
21211 Baltimore
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
60325 Frankfurt am Main
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
NG7 2RD Nottingham
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
NG9 4AP BEESTON
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.