Objective
Long term humoral immunity essentially relies on two types of cells exported from germinal centers (GC): plasma cells (PCs), which secrete antibodies, and memory B cells (MBCs). Both subsets of cells can survive for decades in humans, being responsible for the extended protection afforded by the most successful vaccines but also therapeutic failures in the context of B-cell mediated autoimmune diseases. Which cells are selected and what drives them to become long-lived, in normal or pathological conditions, remains a central question in immunology. Studies in humans have so far been curtailed by the limited amount of material available and the lack of longitudinal access to lymphoid organs. This proposal aims to address three intertwined questions for understanding the selection mechanisms underlying protective and pathogenic long-lived humoral immunity: 1. What are the cellular and molecular mechanisms driving the contraction of the MBC response in a vaccine/infectious setting? 2. Do PCs targeting a self-antigen or a vaccine/viral antigen differ in their selection, transcriptomic profile and maintenance? 3. What drives effective/defective self-reactivity purging in vaccine and pathogenic GC-dependent antibody repertoire? To tackle these questions, we have garnered unique access to key lymphoid tissues (spleen and bone marrow) involved in the initiation and long-term maintenance of the immune response from vaccinated donors and patients with a prototypic B cell-mediated autoimmune disease (immune thrombocytopenia, ITP). We believe this set of samples puts us in an ideal position, combining innovative and integrated single cell experimental approaches, to perform an in depth functional analysis of viral- and self-antigen-specific GC, MBCs and PCs and further advance our understanding of long-lived humoral immunity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2024-COG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
94010 Creteil
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.