Objective
Inflammation is an immunovascular process occurring upon pathogen infection and pathological conditions. Strong evidence from the last two decades shows that termination of inflammation is not a passive process but instead, is actively terminated. Such Inflammation Resolution (IR) stops tissue damaging processes while enhancing immune response and tissue repair. Enhancing IR has the potential to improve treatments in chronic inflammation, autoimmune diseases, atherosclerosis, neurodegeneration and cancer. Specialized Pro-resolving Mediators (SPMs) are lipid-derived molecules with a pivotal role in inducing IR and act through putative orphan G protein-coupled receptors (GPCRs) on the surface of immune cells (some acting through unknown receptors). Despite the high relevance of SPMs in IR and the treatment of inflammation-related diseases, there is scarce knowledge in their functional mechanisms, as well as in their relative and absolute effect.
In the ReSolVer proposal we will use chemical synthesis, chemoproteomics, signaling, structural biology and primary 3D epithelioids to understand SPM mechanisms and provide a cell/tissue/disease inspecific SPM-receptor network so as to tackle the pleitropic effects of SPMs in different organs/disease. More specifically, we will:
(i) Identify, validate and de-orphanize SPM receptors, using chemoproteomics, in vitro binding and signaling assays,
(ii) Generate a functional SPM-receptor network, of SPM-receptor interactions, signaling profiles and cell expression levels,
(iii) Determine the structural mechanisms of SPM-receptor interactions, using cryo-EM of SPM-receptor complexes and functional assays,
(iv) Design and test synergistic SPM therapeutic strategies, based on the generated SPM-receptor network and human 3D primary epithelioids,
The results will provide a breakthrough in inflammation resolution, tackle GPCR de-orphanization and open new therapeutic avenues in inflammation-related diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- medical and health sciences clinical medicine oncology
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2024-COG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
50009 Zaragoza
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.