Project description
Extracting, modelling and analysing the brain’s vascular network in ageing
The brain’s vascular system is essential for its function, yet our knowledge of it remains limited compared to other extensively studied organs. Methodological challenges hinder the development of large-scale spatio-temporal neurovascular atlases, limiting insights into the neurovasculature’s role in pathology and ageing. The ERC-funded CARAVEL project aims to transform neurovascular image analysis by creating the first population atlas of brain vascular ageing and establishing a robust framework for modelling and analysing the brain’s vascular network. This research will enable an unprecedented examination of the brain’s vascular system with both the atlas and framework freely available to the scientific community. By facilitating new hypotheses and improving clinical applications, the project is expected to have a significant impact on both society and the economy.
Objective
The brain vessel tree is essential to brain function. However, we still have limited knowledge about this structure compared to other organs that have been extensively studied. While atlases have been helpful in advancing our understanding of the brain in neurosciences, the same progress has not been seen for the brain vessel tree. Its extraction, modelling, and analysis still pose several methodological challenges, making it impossible to accurately, robustly, reliably, and reproducibly quantify and compare it across individuals within large populations. As a result, brain vascular atlases that provide a comprehensive representation of the brain vessel tree are scarce, and the existing ones face important limitations. This is a critical bottleneck towards understanding the role played by the neurovasculature in pathology onset, ageing, and well-being.
CARAVEL is an ambitious project at the intersection of biomedical imaging, neuroscience, computer vision, statistics and medicine, aiming to transform neurovascular image analysis. It will devise a radical new approach to build and provide the first population atlas of brain vascular ageing, encompassing multiple scales, and it will formulate a robust and reliable methodological framework to accurately extract, model and analyse the brain vessel tree in a reproducible way. Our efforts will enable the study of the brain's vascular system at a scale that is currently unattainable.
The atlas and its methodological framework will be freely available to the scientific community. This will help clinicians and researchers to test and validate new hypotheses, discover knowledge about the brain vessel tree and its interaction with the brain, and contribute to numerous clinical applications. Hence, CARAVEL shall have a tremendous impact on society and the economy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been validated by the project's team.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been validated by the project's team.
- natural sciences biological sciences neurobiology
- natural sciences computer and information sciences software
- medical and health sciences clinical medicine angiology vascular diseases
- natural sciences computer and information sciences artificial intelligence computer vision
- medical and health sciences basic medicine pathology
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2024-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
06410 BIOT
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.