Objective
The NANOBEAT consortium is focused on addressing the significant issue of impaired cardiac conductivity and its associated cardiac arrhythmias in the European Union. These conditions affect around 13-22 million people in the European Union alone.
Two of the most important arrhythmias in this context are Atrial Fibrillation (AF) and Left Bundle Branch Blocks (LBBB The debilitating consequences of LBBB and AF include stroke, HF, and death and also contribute greater than 2.6% of the annual healthcare expenditure in the EU.
Currently available therapies for AF and LBBB have limited effectiveness, with efficacy rates ranging from 35-60% in patients. These therapies are also associated with low biocompatibility and require costly follow-up treatment.
The NANOBEAT consortium aims to develop a new medical device called CardioINK - a composite biomaterial composed of noble metal-based nanowires in a collagen-alginate hydrogel delivered to damaged cardiac tissue using specialized minimally invasive catheters. The nanowires self-assemble in the damaged areas, restoring cardiac signaling conductivity and resolving the negative effects of AF and LBBB.
Preliminary results from porcine animal models treated with CardioINK have shown 100% efficacy in diminishing the negative effects of LBBB and AF. The ultimate goal of the consortium is to ready CardioINK for first-in-human trials by project end. NANOBEAT will also develop a commercialization and regulatory strategy to introduce CardioINK to both the EU and US markets. Recognizing the importance of including the patient perspective in the development process, NANOBEAT will establish patient advisory boards to ensure that the patient voice and needs are integrated into the development of CardioINK in all stages.
Overall, the NANOBEAT consortium's efforts to develop CardioINK have the potential to revolutionize treatment options for individuals with impaired cardiac conductivity and significantly improve patient outcomes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine cardiology cardiovascular diseases cardiac arrhythmia
- medical and health sciences basic medicine neurology stroke
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.4 - Digital, Industry and Space
MAIN PROGRAMME
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HORIZON.2.4.4 - Advanced Materials
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-IA - HORIZON Innovation Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-CL4-2024-RESILIENCE-01-TWO-STAGE
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
69120 HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.