Metal-Organic-Framework Kinetic Array for Diabetes Detection

Información del proyecto

MOFKADD

Identificador del acuerdo de subvención: 101188997

DOI

10.3030/101188997

Proyecto cerrado

Fecha de la firma de la CE 22 Octubre 2024

Fecha de inicio 1 Noviembre 2024

Fecha de finalización 30 Abril 2026

Financiado con arreglo a

• European Research Council (ERC)

Coste total

Sin datos

Aportación de la UE

€ 150 000,00

Coordinado por

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

Periodic Reporting for period 1 - MOFKADD (Metal-Organic-Framework Kinetic Array for Diabetes Detection)

Período documentado: 2024-11-01 hasta 2026-04-30

Resumen del contexto y de los objetivos generales del proyecto

Diabetes mellitus (DM) is a major global health challenge, affecting 537 million people worldwide and causing over 6.7 million deaths annually. If not properly managed, DM can lead to severe complications, including vision loss, vascular damage, kidney dysfunction, nerve damage, and ultimately death. The disease comprises two main types: type 1 diabetes (T1DM), characterized by insufficient insulin production, and type 2 diabetes (T2DM), associated with impaired insulin utilization.
Current diagnostic and monitoring methods rely predominantly on blood-based measurements, which are invasive, time-consuming, and costly. In this context, breath analysis has emerged as a highly promising alternative. It offers the potential to (i) enable large-scale, non-invasive screening of populations, (ii) monitor individuals at risk of developing DM, and (iii) provide patients with a painless and convenient tool for continuous self-monitoring. Specific volatile organic compounds (VOCs), such as acetone, propane, and ethanol, have been identified as a relevant biomarker cluster for DM diagnosis and monitoring.
However, translating breath analysis into practical diagnostic tools remains challenging. Target VOCs are typically present at low concentrations (ppm levels) and must be detected selectively in the presence of numerous interfering compounds, including other VOCs and high levels of humidity. In addition, natural variability in baseline VOC levels between individuals and over time necessitates frequent and reliable measurements using portable devices.
Current state-of-the-art technologies present a clear trade-off: highly selective analytical techniques (e.g. laboratory-based instruments) are expensive, bulky, and require skilled operators, while portable and low-cost sensors often lack the selectivity and stability required for reliable measurements, frequently suffering from issues such as baseline drift.
Within this context, there is a strong need to bridge this gap by developing a miniaturized and elegant sensing platform capable of accurate detection of VOC biomarkers in complex breath mixtures while

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

A capacitive demonstrator sensor integrating custom-designed microhotplates was successfully developed and fabricated. This required the optimization of the sensor architecture and fabrication process to ensure reliable operation of both the capacitive transducers and the integrated heating elements.

To enable multiplexed measurements, multiple sensors were integrated on a single chip carrier, resulting in a compact sensor array platform with dedicated electrical interfacing and readout capabilities. A major focus was the integration of the metal-organic framework (MOF) as the active sensing layer. Deposition procedures were developed and optimized to achieve homogeneous coatings while maintaining sensor functionality.

The fabricated demonstrator was subsequently evaluated through sensing studies under controlled conditions. The results demonstrated the successful functioning of a kinetic MOF-based sensor with the integrated microhotplates unlocking a miniaturized temperature-controlled operation for kinetic VOC detection.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

The project successfully met its targeted objectives. As a form of quantitative comparison, one ZIF-8 kinetic sensor was benchmarked against a state-of-the-art electronic nose, consisting of 10 MOx sensors. The single kinetic sensor easily outperformed the combined output of 10 MOx sensors.
The potential impact of this advancement is substantial, both economically and socially. With further development, these sensors could transform medical diagnostics by enabling non-invasive, efficient, and cost-effective approaches to diabetes detection and monitoring. This would facilitate earlier intervention, improve patient outcomes, and contribute to reducing healthcare costs. Beyond diabetes, the detection of acetone can be readily extended to other application domains, including performance monitoring in endurance sports, tracking of ketogenic diets, and health monitoring in elderly populations, further broadening the technology’s societal relevance and market potential.
Further steps needed towards the valorization of this demonstrator (i) further research and development. The array must be directed towards more complex synthetic mixtures. (ii) Demonstration and validation, and, Patient-based samples need to be included and the demonstrator needs to be validated. (iii) Product compliance, further elaborate quality management systems (QMS) and ISO norms needed for CE certification.