Objective
Osteoporosis is a major concern in Europe, resulting in 4.3 million fragility fractures and health care costs in excess of €56 billion annually. Bone, a smart material, can detect microcracks or microdamages and to repair these microdefects due to its growth and remodeling capabilities in the presence of electro-mechanical stimuli. Dry and wet bone involve matrix piezoelectricity, namely a coupling between deformation and polarization. Flexoelectricity, the phenomenon coupling deformation gradients and polarization, still presents experimental and theoretical challenges.
Bone biomechanics has been resistant to progress due to the complexity of the propagation of information across the scales of the bone hierarchical microstructure and the multidisciplinary nature of bone biomechanics. BONEREPAIR has the potential to provide a global vision of the effects of electro-mechanical signals on bone remodeling and healing, from the cellular to tissue level, by:
1) Characterizing the response of bone to electro-mechanical stimuli, from cellular to tissue level, via dedicated experiments on biomaterials and bone explants based on novel Bone-on-Chip systems,
2) Modelling the bone cells' response to electro-mechanical stimuli and their gradients, and incorporate them into a unified field theory of bone remodeling and healing, and
3) Designing adequate electro-mechanical stimuli promoting bone healing more efficiently.
We hypothesize it is possible to heal bone by applying well-calibrated electro-mechanical stimuli, from the cellular level up to the tissue level, by using multiscale methods to upscale electro-chemo-mechanical phenomena – including piezoelectricity, flexoelectricity, and damage – from microcrack scale up to the tissue level.
BONEREPAIR will moreover largely contribute to the development of novel homogenization methods towards generalized continua for composite materials showing multiphysical behavior like piezoelectricity and flexoelectricity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biophysics
- engineering and technology industrial biotechnology biomaterials
- engineering and technology electrical engineering, electronic engineering, information engineering electrical engineering piezoelectrics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2024-ADG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
54052 Nancy Cedex
France
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