Project description
Non-invasive thermal mapping of tissues
Early detection of biological tissue abnormalities is central for effective treatment. In biomedical engineering, reconstructing thermal and structural tissue properties can provide valuable insights into health conditions. One key challenge is estimating blood perfusion, a critical factor in heat transfer. With the support of the Marie Skłodowska-Curie Actions programme, the IWFM project aims to develop a novel, non-invasive approach to identify biological properties based on thermal-wave heat transfer. The team will measure temperature at tissue boundaries and produce algorithms to mathematically reconstruct blood perfusion. The proposed solution can help monitor the integrity of biological tissues as well as tumour formation and growth.
Objective
Many practical applications related to biomedical, wind, seismic or noise excitations require reconstructing structural properties from the knowledge of some appropriate output responses. In the field of biomedical engineering, the importance of the topic can easily be demonstrated by the significant impact on organs malfunctioning caused by abnormalities within biological tissues, such as tumour formation and growth. These disorders must be detected and treated early in order to save lives and improve the general health. Understanding the heat transfer in biological tissues and, in particular, the determination of tissues properties and the blood perfusion rate are important yet difficult tasks, and, in such sense, this project will seek to maximise the efficiency in providing rapid, intelligent and cost-effective solutions to unexplored impactful challenges. To contribute to achieving such an admirable goal, this proposal aims to accomplish, for the first time, the nonlinear identification of biological properties in thermal-wave heat transfer using inverse methods that are non-invasive and non-destructive. More concretely, reconstructions of the time- or space-dependent blood perfusion coefficient in the hyperbolic thermal-wave equation from transient measurements of the temperature at tissues boundary will be investigated. This analysis requires understanding the ill-posedness of the new inverse nonlinear problems for hyperbolic partial differential equations that are formulated to govern the heat propagation in biological tissues. Proving the uniqueness and stability of solution using the technique of Carleman estimates will be challenged, and developing globally convergent and stable methods of reconstruction will be attempted. Moreover, to add practical significance to the research in a way that may ultimately help to monitor and control the integrity of biological tissues, noisy numerically simulated and experimentally measured data will be inverted.
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Keywords
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
LS2 9JT Leeds
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.