Objective
Over 100M people in Europe live with a digestive disorder, and this number is rising. The gastrointestinal (GI) tract is a complex ecosystem which facilitates digestion and regulates food intake in addition to regulating immune function in order to effectively guard against pathogens while tolerating innocuous antigens. It also acts as a sensory organ. The GI tract is connected with the brain via neuronal and hormonal signalling pathways which form the gut-brain axis (GBA). Dysregulation of the GBA contributes to local pathologies such as inflammatory bowel disease and is implicated in the development of neuropathologies such as Parkinson’s and multiple sclerosis. Technologies for diagnosis of gastrointestinal (GI) dysfunction are underdeveloped and have not found widespread clinical utility. GI tract complexity has made it difficult to measure GI function and collect spatio-temporal information that could improve diagnosis or treatment. CODEBREAKER will generate a suite of conformal conducting polymer devices which interface with the GI tract, elucidating pathways of the GBA in health and disease. To do this we will develop new methods to measure key functions of gut: 1. Gut permeability (barrier integrity), 2. gut motility, and 3. enteric nervous system function. Recent, key technology advances in my group set the groundwork to enable CODEBREAKER. Our devices offer unparalleled functionality monitoring that can be applied on a variety of models and tissues of varying complexity. Where possible, devices will be tested on advanced tissue engineered models in vitro and perfused ex vivo tissues (e.g. rodent and pig). Where functionality is lost ex vivo or in vitro, in vivo experiments will be used. We will also investigate the use of permeability as an in vivo diagnostic compatible with endoscopy. CODEBREAKER has the potential to yield huge dividends in our understanding of how gut function and diet can affect our health, not just in the gut but also the brain.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been validated by the project's team.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been validated by the project's team.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2024-ADG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.