Objective
Fluorescence sensing materials enable detection of biologically active molecules at the cellular level, whereas photo-responsive materials for molecular uncaging allow controlling cellular processes. Would it be possible to merge these two research fields? The aim of CaptuRel is intelligent fluorescent nanomaterials undergoing bioinspired cycle of specific capture/sensing and photorelease of naturally present bioactive species, protons and neurotransmitters (NTs), for sensing and controlling chemical gradients at the biological interface. These CaptuRel materials will use protons and NTs as messengers to establish chemical communication with other materials and cells in a two-way detection-action regime. They will be applied for sensing and controlling activity and connections of neurons. The project is composed of three work packages. (1) We will establish concepts of fluorescent artificial receptors that exploit adaptive and dynamic covalent chemistry with fluorescent dyes and recognition ligands in nanoparticles for specific reversible capture/sensing of NTs. They will change their fluorescence color/intensity on specific capture of NTs and lose their affinity to NTs at low pH. (2) We will introduce photoacid nanomaterials capable to generate and control pH gradients at distances 0-1000 nm and apply them for short-distance chemical communication with materials and cells. (3) We will obtain CaptuRel materials capable of NT capture and photorelease by coupling artificial receptors with photoacids. They will sense and control NT gradients at 1-100 µm distances and enable us to establish principles of long-distance material-material and material-cell communication based on NTs. This high-risk/high-gain multidisciplinary project will establish a paradigm-shifting concept of a nanomaterial capable to capture bioactive molecules in situ, allowing sensing biological events and then photorelease these molecules to control in space and time bio-activity at cellular level.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
- polymeric nanoparticles
- polymeric nanofibers
- light-responsive materials
- fluorescence sensing
- fluorescent dyes
- probes
- dynamic covalent chemistry
- photorelease
- photocages
- photoacids
- photo-responsive materials
- molecularly imprinted polymers
- artificial receptors
- chemical communication
- neurotransmitters
- neuromodulators
- cell membrane
- nanomaterial-cell interactions
- biosensing
- cellular imaging
- neural stimulation
- synaptic plasticity
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2024-ADG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.