Skip to main content
Go to the home page of the European Commission (opens in new window)
English English
CORDIS - EU research results
CORDIS

Advancing Bio-purification of Anti-cancer Therapeutic Peptides via Crystallization using Surface Modified Heteronucleants

Objective

Peptides are emerging as next generation therapeutics with a promise of treating cancers and metabolic disorders. This is due to their high specificity, precise targeting, small size, ease of modification, and excellent biocompatibility. Despite the acceleration of peptide drug discovery with >800 drugs in clinical trials, the separation and purification processes remain a challenge, requiring sustainable downstream processing. Thus, there is a need for more efficient purification methods to keep pace with peptide-based drug advancements. PetalPure introduces an innovative crystallization-based purification process using surface-modified heteronucleants to enhance the crystallizability of challenging anti-cancer peptides. This multidisciplinary project involves developing solubility models, size-based peptide classification, heteronucleant selection and modification, crystallization process design, and experimental frameworks for broader application. PetalPure aims to provide a more affordable alternative to chromatographic separation, eliminating the need for expensive resins and reducing solvent consumption and waste, in line with the Sustainable Development Goal (SDG) of Responsible Consumption and Production. Additionally, it will lower the time and cost of peptide manufacturing, facilitating wider access to affordable and effective healthcare, contributing to the SDG of Good Health and Well-being. Prof. Heng, with his extensive experience in biopharmaceutical manufacturing and being a leader in peptide crystallization, is an ideal supervisor for this project. Imperial, with its research excellence and experience with MSCA postdoctoral fellows, will offer a supportive environment for PetalPure. This project will play a pivotal role in making me a leading academic by allowing high-impact research, training on teaching, supervision, and other transferable skills as well as long-term collaboration opportunities with pharmaceutical industry and academics.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.

You need to log in or register to use this function

Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

See all projects funded under this funding scheme

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) HORIZON-MSCA-2024-PF-01

See all projects funded under this call

Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 260 347,92
Address
SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
SW7 2AZ London
United Kingdom

See on map

Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data
My booklet 0 0