Project description
Novel molecular players in inflammation
Inflammation is an immune response to injury, infection or other harmful stimuli. During inflammation, various cell types such as neutrophils and macrophages release inflammatory mediators to attract other cells and promote tissue repair. With the support of the Marie Skłodowska-Curie Actions programme, the VWF-MISS project focuses on Von Willebrand factor (VWF), a molecule known for its role in haemostasis. Researchers plan to investigate the role of VWF in inflammation and in particular in the regulation of macrophage biology. They will dissect VWF signalling and identify the receptors involved. Moreover, by studying how specific VWF domains or mutations affect inflammatory signalling, they will provide fundamental understanding of VWF and inflammatory disease.
Objective
Von Willebrand factor (VWF) is a large multimeric glycoprotein that circulates in plasma and plays a key role in primary hemostasis at sites of vascular injury. In addition, recent studies have highlighted a novel role for VWF in regulating inflammation in multiple human pathologies, including cardiovascular disease, von Willebrand disease, and several cancers. Notwithstanding these findings, the biological mechanisms through which VWF exerts its immunomodulatory effects remain poorly understood. The overarching aim of the VWF-Macrophage Intracellular Signalling Study (VWF-MISS) is to gain novel insights into the molecular mechanisms through which VWF regulates macrophage biology over the course of an 18-month fellowship. Specifically, VWF-MISS will characterize i) the macrophage receptors involved in modulating the pro-inflammatory response, ii) the molecular basis involved in the temporal regulation of VWF signalling, and iii) the role of specific VWF domains and/or mutations in regulating macrophage inflammatory signalling using a wide range of in vitro laboratory strategies and bioinformatics (RNA-sequencing). As such, the applicant will integrate existing expertise from the Royal College of Surgeons in Ireland O’Donnell laboratory (VWF biology; host organisation) and Trinity College Dublin Fallon laboratory (innate immunity; secondment) to address these research objectives. The concept that VWF plays a key role at the interplay of hemostasis and inflammation has clear translational relevance with respect to both bleeding and thrombosis and presents the intriguing possibility that specific targeting of the VWF-macrophage interaction could offer exciting therapeutic opportunities. The VWF-MISS project will equip the applicant with transferable laboratory and analytical skills, that, combined with her clinical background, will significantly advance her career goal to direct a scientific research program relating to the crosstalk between hemostasis and immunity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pathology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
D02 YN77 DUBLIN 2
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.