Objective
Non-steroidal anti-inflammatory drugs (NSAIDs) are typically used to reduce inflammation, pain, and fever. However, under UV light, NSAIDs can undergo photochemical reactions in wasterwater, generating toxic radicals that threaten aquatic life and human health. UnPAIN arises as a solution to both understand and avoid this social problem. Previous spectroscopic studies have yielded inconsistent results regarding the mechanism, hindering rational design. UnPAIN will provide time-resolved chemical information to answer some fundamental questions such as the difference in photostability, considering both structural and environmental factors, bringing together advanced quantum chemical methods and computational simulations in the excited state for some representative NSAIDs such as ketoprofen, tiaprofenic acid, suprofen, naproxen and ibuprofen. This challenge includes dealing with multiple electronic states, internal conversion, intersystem crossing, and accurately describing anionic systems and solvents. The knowledge gained from this research could lead to safer drug designs and more stable formulations. Simultaneously, UnPAIN is designed to establish a robust protocol for studying in a general way photodissociative processes, which will be extremely useful for the scientific community. The experienced researcher will share knowledge on non-covalent interactions, and reaction mechanisms to the host group, while acquiring expertise in emerging quantum chemical methods and time-resolved chemical phenomena. UnPAIN will equip the applicant with the foundation needed to pursue an independent career, fostering a unique and highly competitive research profile. Additionally, it will offer excellent training, an enhanced scientific network, and a comprehensive set of essential soft skills, including communication, management, dissemination, and public engagement.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1010 WIEN
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.