Project description
New methods for creating high-value amines
Amines serve as fundamental components in pharmaceuticals, agricultural products and advanced materials. Researchers frequently modify them with additional chemical groups to enhance reactivity, binding and solubility. However, standard synthesis methods remain slow and are restrictive in terms of diversity. With the support of the Marie Skłodowska-Curie Actions programme, the CYBO project aims to introduce an innovative strategy that transforms a simple amine, called homoallylic amine, into more complex and valuable structures. The approach uses a borane molecule to trigger a unique chemical reaction that leads to the formation of new cyclic amines. The trigonal planar geometry of the borane molecule offers a versatile platform for the synthesis of amines that could be exploited in drug discovery.
Objective
Functionalized amines are high-value materials with numerous applications as therapeutic agents, agrochemicals and organic materials. The development of strategies for enabling the fast and divergent synthesis of these material can have a positive impact to our ability to discover, manufacture and evolve molecules of high-relevance to our society.
In this proposal we present an innovative approach for the functionalization of homoallylic amines based on their coordination borane (BH3). This will provide access to novel boryl radical species that we will exploit in cyclization-functionalization cascade. This novel reactivity mode will convert the homoallylic amine into a cyclic borylated and functionalized building block that can be further diversified across the sp3 C–B bond by oxidation or Suzuki-Miyaura cross-coupling.
Overall, this strategy will constitute a divergent platform for the diversification of high-value amines and also a novel retrosynthetic tactic for the preparation of high-value and structurally complex drug analogues.
This research squarely fits within the expertise of the Leonori group in the generation and use of boryl radicals in synthesis and catalysis.
The completion of such an innovative and ambitious project at RWTH Aachen University will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance the Researcher future career following the training plan envisioned.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences chemical sciences catalysis
- natural sciences chemical sciences organic chemistry amines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
52062 Aachen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.