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Efficient Synthetic Cell FDCA Production via an Integrated One-Pot Catalytic Process

Project description

Nature-inspired, green one-pot process to produce FDCA

In the transition to greener chemistry, so-called one-pot multi-step catalytic processes carry out multiple reaction steps in a single vessel without isolation of intermediates. This is more efficient, reduces waste and cost, and lowers environmental impact. 2,5-Furandicarboxylic acid (FDCA) is a bio-based chemical compound with the potential to replace petroleum-derived terephthalic acid in the production of plastics. Inspired by nature and with the support of the Marie Skłodowska-Curie Actions programme, the SynCell project aims to produce FDCA in a one-pot process leveraging the spatially distinct catalytic zones of metal-organic frameworks. Inexpensive and widely available sugars and polysaccharides will be the feedstock, dissolved using green ionic liquids or deep eutectic solvents.

Objective

"SynCell aims to develop multicatalytic systems capable of performing multiple synthetic steps in sequence and under controlled conditions within a single process, reducing the need for external intervention and lowering environmental impact. Its primary objective is to emulate nature's ability to regulate macroscopic functions, by creating a ""one-pot"" method for synthesizing 2,5-furandicarboxylic acid (FDCA) from inexpensive and widely available sugars and polysaccharides.
To achieve this, SynCell integrates various design principles into a unified system, utilizing Metal-Organic Frameworks (MOFs) as key components. MOFs provide distinct advantages, including high structural regularity, adjustable pore sizes, and uniform metal distribution. These features allow MOFs to act as multifunctional scaffolds, creating spatially distinct catalytic zones that enable complex, sequential reactions through compartmentalized catalytic sites. Additionally, Ionic Liquids (ILs) or Deep Eutectic Solvents (DES) can be employed as alternative media for effectively dissolving glucose (Glc) and polysaccharides. These solvents not only improve dissolution but also boost catalyst performance, creating a more efficient reaction environment.
The combined use of multicatalytic MOFs with ILs or DES will result in a novel, environmentally friendly process for producing FDCA. This process, inspired by biological systems, enables the transformation of cheap, readily available sugars or polysaccharides without the need for intermediate purification or isolation."

Fields of science (EuroSciVoc)

Keywords

Programme(s)

Topic(s)

Funding Scheme

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

(opens in new window) HORIZON-MSCA-2024-PF-01

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Coordinator

UNIVERSITAT JAUME I DE CASTELLON
Net EU contribution
€ 194 074,56
Address
AVENIDA VICENT SOS BAYNAT S/N
12006 Castellon De La Plana
Spain
Region
Este Comunitat Valenciana Castellón/Castelló
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data

Partners (1)