Project description
Smarter cardiovascular repair with novel stents
Cardiovascular diseases are usually caused by narrowed or blocked blood vessels and constitute a leading cause of death worldwide. Traditional metal stents can restore blood flow, but they often cause complications due to their rigidity and limited adaptability. With the support of the Marie Skłodowska-Curie Actions programme, the MagStents project proposes to develop soft, biocompatible stents made from hydrogels that contain magnetic nanoparticles. These innovative stents will be guided and adjusted remotely using an external magnetic field, offering minimally invasive treatment with greater precision and flexibility. After optimising the magnetic and mechanical properties of these materials, researchers plan to test their safety and performance to improve the outcome for patients requiring vascular intervention.
Objective
Cardiovascular diseases represent a critical global health challenge, affecting millions through the obstruction of blood vessels. Existing interventions, particularly conventional stents, are hindered by significant limitations such as rigidity and a high risk of restenosis. This proposal introduces MagStents, an innovative fusion of soft polymers and magnetic nanoparticles, designed to overcome these challenges. While traditional metal stents restore blood flow, they are constrained by inflexibility and potential vessel damage. In contrast, MagStents offer a biocompatible, flexible, and self-expanding alternative, constructed from dual crosslinked hydrogels.
A key advancement of MagStents is their magnetic actuation, enabling precise positioning, adjustment, and post-deployment control using an external magnetic field. This capability introduces a novel dimension in cardiovascular intervention, reducing the need for surgical procedures by allowing real-time non-invasive adjustments.
The research will focus on the development of Magnetic hydrogels (MagGels), engineered with controlled magnetic and mechanical properties. Advanced additive manufacturing technique will be employed to fabricate MagStents that incorporate these MagGels, ensuring both structural integrity and magnetic responsiveness. Comprehensive evaluations will assess biocompatibility, mechanical performance, and magnetic behavior, alongside the potential for controlled drug release in vitro.
MagStents offer a significant advancement in interventional cardiology by enabling remote, non-invasive manipulation and enhanced adaptability. The research aims to establish a new standard for stent performance, improving patient outcomes and addressing the current limitations of cardiovascular disease treatments. Through their unique combination of magnetic control and biocompatibility, MagStents hold the potential to revolutionize stent technology and patient care.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering composites
- natural sciences chemical sciences polymer sciences
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- engineering and technology nanotechnology nano-materials
- engineering and technology mechanical engineering manufacturing engineering additive manufacturing
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
602 00 BRNO STRED
Czechia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.