Project description
X chromosome genes and T cell immunity
The X chromosome carries many immune-related genes. In females, one X chromosome is usually inactivated in each cell, but some genes escape this process and are expressed from both X chromosomes. This explains why women typically mount more robust immune responses than men. With the support of the Marie Skłodowska-Curie Actions programme, the X-CITE project aims to uncover how the X chromosome immune-related genes that escape inactivation affect T cell function. By studying the molecular mechanisms, the project is designed to reveal how sex-biased gene expression shapes immune responses. Ultimately, these insights could guide strategies to enhance T cell-based cancer immunotherapies, improving treatment outcomes for both sexes.
Objective
Sex differences play a significant role in immune function, with women generally mounting stronger immune responses than men. A key factor behind these differences is the X chromosome, which contains many genes that are important for immune function. In females, who have two X chromosomes, one of the X chromosomes is usually inactivated in each cell to prevent an overdose of X-linked gene expression. This process is known as X-chromosome inactivation (XCI). However, some genes can escape this inactivation and are expressed from both X chromosomes. These escapee genes are often expressed at higher levels in females than in males, who only have one X chromosome. The X-CITE (X-Chromosome Inactivation and T cell Escape) project aims to elucidate the molecular mechanisms by which these XCI escapee genes influence T cell responses. Understanding these mechanisms is crucial, as T cells are central to the success of cancer immunotherapy, where sex-based differences in T cell function may impact treatment outcomes. By exploring the sex-biased expression of XCI escapee genes, this project will advance our understanding of sex differences in immune responses and provide new insights into how T cells can be manipulated to improve the efficacy of cancer immunotherapy. The research will be conducted at the Landsteiner Laboratory Amsterdam UMC-Sanquin (The Netherlands), under the supervision of Dr. Monika Wolkers, whose lab specializes in T cell biology and the enhancement of T cell functions in immunotherapy settings.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine immunology immunotherapy
- natural sciences biological sciences genetics chromosomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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1006 AN Amsterdam
Netherlands
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