Project description
Optimised nanoparticles for in vivo delivery
Nanoparticles have gained significant attention for their potential in drug delivery. When they are exposed to physiological fluids, a layer of proteins forms on their surface known as a corona. This can profoundly influence their behaviour and effectiveness in vivo. With the support of the Marie Skłodowska-Curie Actions programme, the GUTCORONA project proposes to design nanoparticles with controlled surface modifications as a way to manipulate protein corona formation in environments like plasma or the gastrointestinal tract. The idea is to introduce a temperature-responsive surface functionality on nanoparticles and then apply a magnet or laser to generate high temperatures and disrupt the corona structure. Ultimately, these nanoparticles will be optimised for drug delivery and imaging, enhancing theranostic applications.
Objective
It is now well recognized that the protein corona formed on particles in physiological fluids has a strong impact on their performance in vivo. Therefore, this project aims to design and develop systematically controlled surface-modified nanoparticles for the formation and on-demand modification of protein corona in plasma or gastrointestinal environments. Firstly, the initial hypothesis is that the structure and composition of the corona formed on nanoparticles will be different with varying temperature-responsive surface functionality. Then, the second hypothesis is that using an alternating magnetic field (AMF) or near-infrared laser (NIR) as two different methods to activate the particles, these nanoparticles will act as internal heating sources generate localized high temperatures to modify the nature of the surface functionality, disrupting the corona structure, thereby enhancing cellular uptake and biological activity. Using this information, the nanoparticles will be optimized for use as theranostic agents, offering preferential accumulation, enhanced drug efficacy, and serving as contrast agents for in vivo and preclinical MRI/CT imaging. Through this Fellowship I will pass on my materials expertise to the host group while gaining new skills and experience at the intersection of colloid science and biology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- engineering and technology nanotechnology nano-materials
- natural sciences physical sciences optics laser physics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.