Project description
Simulating the effects of new diabetes therapies
People with diabetes must constantly monitor and regulate their blood sugar levels, even when using automatic insulin delivery (AID) systems. However, mealtime insulin dosing still requires human input and is prone to error. Adjunctive therapies such as GLP-1 receptor agonists can help reduce post-meal glucose spikes, but existing diabetes simulators used to develop AID systems do not consider the effects of these drugs. With the support of the Marie Skłodowska-Curie Actions programme, the T1SIA project will fill this gap by developing the first type 1 diabetes simulator to incorporate GLP-1 dynamics. This enhanced tool will support the development of safer therapies and digital twins, enabling researchers and industry to test treatments virtually.
Objective
People with type 1 diabetes (T1D) live with the burden of self-managing their glucose levels. Although automatic insulin delivery (AID) systems have alleviated this load, patients still need to count carbohydrates and administer insulin boluses at mealtimes, making the systems prone to human errors, which could have severe health consequences. Adjunctive therapies such as GLP-1 receptor agonists aim to mitigate these risks by reducing the impact of meals on the glucose rate of appearance in blood. These drugs are prescribed for type 2 diabetes, but they are currently being considered for their use in T1D. Simulators are one of the essential tools for developing AID systems and the foundation for digital twins, allowing testing and validating control algorithms while avoiding any risks for the patients. However, no T1D simulator includes descriptions of GLP-1 effects. The T1SIA project will develop a T1D simulator that includes a mathematical model of GLP-1 receptor agonists’ dynamics. This 2-year project will rely on the experience of the University of Bern and the Polytechnic University of Valencia. The first year at Bern will focus on developing a GLP-1 mathematical model, supervised by an expert in AID systems and a clinician expert in adjunctive therapies. In the second year at Valencia, the model will be integrated into a T1D simulator alongside a cohort of virtual patients under the supervision of an expert in diabetes technology. T1SIA will allow exploring the contributions of these novel therapy drugs for research and product-development purposes in the AID and pharmaceutical industry. This project will push the candidate’s professional development, both for academic and industry positions, improving her knowledge of mathematical modeling, human physiology, and identifiability processes while also providing the candidate with skills in project management, networking, teaching and supervision, and communication.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine physiology
- natural sciences mathematics applied mathematics mathematical model
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
46022 Valencia
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.