Project description
Engineering enzymes for new bioactive molecules
Fluorine plays a vital role in drug development due to its unique chemical properties. However, it is rarely used by nature in the biosynthesis of complex molecules. With the support of the Marie Skłodowska-Curie Actions programme, the Bio-fluorine project addresses that gap by exploring how biosynthetic enzymes can be used to incorporate fluorine into terpenoids, the largest and most structurally diverse class of natural products. To develop a fully biological method for inserting fluorine from simple precursors into diverse carbon frameworks, researchers will harness enzymatic pathways. A yeast-based production system will facilitate the scalable synthesis of new fluorinated natural products, paving the way towards pharmaceutical innovation.
Objective
Fluorine offers unique properties that are invaluable in molecular design and discovery. Its importance is evidenced by the
overrepresentation of fluorine among synthetic small molecule therapeutics. However, unlike synthetic chemists, nature rarely uses fluorine as part of its design tools to construct bioactive molecules. To introduce fluorine into complex scaffolds such as natural products would offer enormous potential for accessing new structural space that combine beneficial features of biological and synthetic molecules for the discovery of novel functions. This proposal, Bio-fluorine, aims to explore the incorporation of fluorine into terpenoids, which constitute the largest and most diverse class of natural products, using biosynthetic enzymes. The proposed research seeks to develop an entirely enzymatic pathway to incorporate fluorine from a simple precursor into diverse carbon skeletons. The proposed work also aims to develop a Saccharomyces cerevisiae chassis for scalable biological fluorine incorporation and novel organofluorine production.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry halogens
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.