Objective
Developing effective membrane transporters is a key challenge for the delivery of nucleic acid-based drugs. Despite the exponential discovery of such biomolecules with therapeutic potential, the majority of them may need to be discarded from further development for being too hydrophilic to cross the lipid membrane. Future delivery technologies require the development of conceptually new approaches that can overcome the emerging limitations of current carriers and strategies. Recently, superchaotropic boron clusters have been validated to activate the transport of a broad range of hydrophilic cargos. The anionic nature of these clusters offers an alternative transport scenario. The clusters will not aggregate with hydrophilic anionic domains and, instead, will be repelled by anions. Therefore, they could be exploited to modify the structure of cargos without altering their solubility and function. The main goal of this action is the connection of superchaotropic boron clusters to hydrophilic biomolecules such as probes and nucleic acids to enable their autonomous membrane transport, while preventing self-aggregation and unspecific interactions with other biological surfaces. This will be achieved through an interdisciplinary approach that will simultaneously provide me with valuable training in chemistry, biology and biophysics, promoting my scientific independence. Short oligonucleotides will be designed to incorporate a variable number of modified nucleosides for future functionalization with boron clusters. Modified oligonucleotides, such as those bearing alkyne or azide functions, will be purchased from commercial sources and combined with cluster derivatives using click chemistry. These new chaotropic oligonucleotide hybrids will allow understanding and validating the application of self-delivering fully anionic nucleic acids with therapeutic potential.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- natural sciences biological sciences biophysics
- natural sciences chemical sciences inorganic chemistry metalloids
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
15782 SANTIAGO DE COMPOSTELA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.