Project description
Injectable self-healing hydrogel for effective bone regeneration
Bone tissue defects pose a challenge in orthopaedic surgery. Current treatments lack the mechanical strength and adaptability required for bone regeneration. Supported by the Marie Skłodowska-Curie Actions programme, the BONEGEL project will develop a self-healing hydrogel for treating non-weight-bearing bone defects. Key innovations include a dextran-based hydrogel that uses cyclodextrin interactions, enhanced with laponite for improved strength and osteoinductive properties, and a controlled release of dexamethasone to promote bone regeneration. The project will also optimise an ex vivo model to test these injectable materials, ensuring their efficacy and safety before clinical application. This work aligns with the EU’s goals for healthcare innovation and sustainability.
Objective
Defects that weaken bone tissue are a major challenge in orthopedic surgery as they can lead to fractures, significant morbidity, and reduced quality of life. Existing treatments do not provide the necessary mechanical strength, adaptability to dynamic bone remodeling, and osteoinductive properties required for effective bone regeneration. The BONEGEL project addresses this gap by proposing an injectable, self-healing hydrogel specifically designed to treat bone defects in non-weight-bearing bone. The BONEGEL approach includes several key innovations: a dextran-based hydrogel that utilizes the host-guest interactions of cyclodextrins to create a dynamic hydrogel that can adapt to irregular bone defects; the incorporation of laponite, a nanosilicate that improves the mechanical strength and osteoinductive properties of the hydrogel; and an effective and safe release of dexamethasone to accelerate bone regeneration. In addition, the project will optimize an ex vivo model for testing injectable materials for bone tissue engineering to ensure the efficacy and safety of the hydrogel prior to clinical application. This interdisciplinary project brings together expertise in materials science, tissue engineering and regenerative medicine to provide a safer and more efficient alternative to current treatments for bone defects and expedite its clinical application. By overcoming the limitations of existing therapies, BONEGEL has the potential to improve patient outcomes and shorten recovery times. This aligns with the EU's priorities for innovation and sustainability in healthcare, ultimately promoting a healthier population and better quality of life for patients. Beyond the scientific, societal and economic impact, this project will advance my career by providing me with the critical knowledge and experience I need to position myself as a leader in the biomaterials and tissue engineering fields and open doors to future academic collaborations and industry partnerships.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
- medical and health sciences clinical medicine surgery
- engineering and technology mechanical engineering applied mechanics
- medical and health sciences medical biotechnology tissue engineering
- natural sciences chemical sciences polymer sciences
- engineering and technology industrial biotechnology biomaterials
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
9220 AALBORG
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.