Project description
Pioneering pancreatic cancer treatment leveraging monoclonal antibodies
Pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer that begins in the cells lining the ducts of the pancreas, accounts for more than 80 % of pancreatic cancers. Treatment options are limited and minimally effective, making it one of the most lethal diseases. PDAC is associated with an overexpression of a cell surface protein that leads to tumour proliferation, invasion, and migration. The ERC-funded PACMAN project aims to provide preclinical proof of concept of treating PDAC with monoclonal antibodies targeting the protein. It will leverage patient-derived PDAC models to investigate therapeutic efficacy and biomarkers associated with treatment response. Success could pave the way for a treatment for this aggressive and deadly disease.
Objective
The PACMAN project aims to develop a novel therapeutic approach for treating pancreatic ductal adenocarcinomas (PDAC), one of the deadliest cancers with limited therapeutic options. The project focuses on targeting an overexpressed cell surface protein in PDAC implicated in tumor proliferation, invasion and migration by driving carcinogenic signaling. This study aims to investigate the ability of a highly specific monoclonal antibody targeting this protein to treat PDAC. By studying the therapeutic efficacy and unravelling associated biomarkers of treatment response in patient-derived PDAC models, the PACMAN program will provide preclinical proof of concept to treat PDAC with a novel class of monoclonal antibodies. Based on a robust patient-derived data package, this innovative approach provides the perspective for a first-in-class therapy for PDAC, addressing a critical unmet medical need and offering new hope for patients with this aggressive cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology prostate cancer
- natural sciences biological sciences biochemistry biomolecules proteins
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2024-POC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.