Project description
Unravelling the gut-brain connection in ADHD
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental condition. Unfortunately, its underlying mechanisms are poorly understood. Recent studies suggest that disruptions in the microbiota-gut–brain axis (MGBA) may contribute to ADHD by triggering neuroinflammation and oxidative stress. Supported by the Marie Skłodowska-Curie Actions programme, the ELEGANCE project investigates how gut microbiota-derived metabolites affect brain cells by using cutting-edge co-cultures of patient-derived microglia and dopaminergic neurons. It will study inflammatory and stress responses and test the potential for microbiota-based restoration. Overall, ELEGANCE aims to identify novel drug targets and pave the way for microbiome-informed therapies and dietary interventions for ADHD.
Objective
The pathophysiology of the most frequent neurodevelopmental disorder in the world, Attention Deficit Hyperactivity Disorder (ADHD), is influenced by the interaction of genetic and environmental risk factors. Studies have been indicating the association between ADHD and changes in the microbiota-gut-brain axis (MGBA), which may cause neuroinflammation, and subsequent microglial activation, secretion of cytokines and oxidative stress in the central nervous system. However, the precise mechanisms remain elusive and choosing a feasible individual-representative model to study pathomechanisms is challenging.
ELEGANCE (“ELucidating the Effects of Gut microbiota-derived metAbolites iN iPSC-derived co-Cultures from ADHD patiEnts”) aims to investigate possible neuroprotective and neurotoxic properties of gut microbiota metabolites in induced pluripotent stem cell (iPSCs)-derived microglia and dopaminergic neurons from ADHD individuals in co-culture. Neuroinflammatory, oxidative stress and metabolic markers will be measured in different contexts (baseline and after treatment with potentially detrimental microbiota metabolites). Potential restoration effects by gut microbiota derived metabolites in compromised phenotypes will be also explored. These findings will elucidate interaction of microglia and dopaminergic neurons and gut microbiota derived metabolites in ADHD and thereby lead to promising novel drug targets. This fellowship will foster collaboration between world leading institutions and top-notch scientists, introducing me to the microbiome field, enhancing my expertise in transcriptomics, bioinformatics, networking and leadership. The project could significantly impact the knowledge about ADHD pathomechanisms and open doors for new treatment and dietary approaches targeting the MGBA.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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91054 Erlangen
Germany
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