Objective
Cable bacteria are multicellular filamentous bacteria found in surface sediments worldwide. They contain highly conductive periplasmic fibers (PCF) and use these fibers for intercellular long-distance electron transfer. The cells in the filament separate their energy metabolism, with most cells buried in anoxic sediment oxidizing sulfide, while a few cells at the surface use the resulting electrons for oxygen reduction. Cable bacteria significantly impact sediment geochemistry, affecting pH, ion mobility, sulfide release, and methane emissions. While their environmental interactions are well understood, the molecular principles for intercellular electron transport are still unclear. It is known that the conductivity of PCF exceeds that of any other biological material and that the PCF contains nickel, likely in the form of a novel nickel-sulfur cofactor but their protein composition was not identified.
My research focus is to unravel the PCF composition and structure, as well as to identify proteins that mediate electron transfer to/from the PCF. I will combine four parallel experimental approaches: metalloproteomics, Cryo-EM, isotope labeling/NanoSIMS, and immunolocalization to study proteins in cell fractionations and in situ in intact cable bacteria. Identifying the highly effective nickel-based bioconductor and its interacting proteins is significant for understanding long-distance electron transfer and the division of labor in these multicellular prokaryotes. Revealing the PCF structure has potential applications for designing fiber polymers, conductive biomaterials, and biodegradable electronics.
Through the interdisciplinary approach of LiveWire, I will expand my scientific expertise in biochemistry, structural biology, and cell imaging under the supervision of leading experts in these fields. In addition, I will improve my leadership, mentoring, and networking competencies to become a future independent research leader.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences earth and related environmental sciences geochemistry
- natural sciences biological sciences microbiology bacteriology
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences chemical sciences organic chemistry aliphatic compounds
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
8000 Aarhus C
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.