Objective
Cyclic AMP (cAMP) is a pivotal secondary messenger that orchestrates a vast range of physiological processes by translating signals from hormones, neurotransmitters, and growth factors. While the intracellular roles of cAMP are well understood, its functions outside the cell remain largely unexplored. The EVOCAMP project seeks to uncover this hidden dimension by exploring how extracellular vesicles (EVs) mediate intercellular cAMP signaling. EVs, a heterogenous group of membrane-bound vesicles, have emerged as key mediators of intercellular communication. This project aims to establish EVs as novel compartments for intercellular cAMP signaling and to elucidate their functional significance in the brain. To achieve this, the project is structured around three objectives: First, to demonstrate that neuron-derived EVs are capable of synthesizing and releasing cAMP into the extracellular space, thereby functioning as novel platforms for cAMP signaling. Second, to map the downstream signaling events triggered by these cAMP-producing EVs in recipient cells, using advanced biosensors to monitor these signaling pathways. Third, to investigate the physiological relevance of cAMP-producing EVs in vivo, using zebrafish embryos to visualize their dynamics, trace their fate, and assess their functions in living organisms. By uncovering a previously overlooked aspect of cAMP signaling, EVOCAMP will reveal a novel mechanism of intercellular communication driven by EVs with significant implications for brain physiology. Furthermore, the skills and knowledge gained through this project will be pivotal in my development as an independent researcher, positioning me at the forefront of interdisciplinary research between cell signaling and extracellular vesicle biology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.