Project description
Smart biomedical Mg alloy solution featuring controlled degradation rates
Magnesium (Mg) alloys have excellent mechanical properties and biocompatibility, making them candidates for medical applications, particularly as alternatives to traditional implants. Their ability to degrade in sync with the body’s healing process eliminates the need for secondary surgery. However, their clinical potential is limited by corrosion in chloride-rich environments, which can pose risks to patients. Supported by the Marie Skłodowska-Curie Actions programme, the DREAM project is developing intelligent biomedical Mg alloys with controlled degradation rates. It will integrate cutting-edge techniques, including convolutional neural networks, advanced Mg alloy research, pH-responsive materials, and density functional theory calculations, to enhance our understanding of Mg-Zn-Ca-RE alloy corrosion and improve their performance in medical settings.
Objective
Magnesium (Mg) alloys, with their excellent mechanical properties, outstanding biocompatibility, and gradual degradation within the body, are demonstrating vast potential for applications in the medical field. Their greatest advantage lies in their ability to degrade in sync with the bodys healing process, eliminating the need for a second surgery to remove traditional implants. However, in chloride-rich physiological environments, Mg alloy implants are prone to rapid corrosion, leading to early failure and posing risks to patient health. To address this challenge, the DREAM project integrates cutting-edge research on Mg alloys, convolutional neural networks (CNNs), density functional theory (DFT) calculations, and pH-responsive materials, with the goal of developing intelligent biomedical Mg alloys with controlled degradation rates. First, the project will establish a comprehensive database of Mg-Zn-Ca-RE (rare earth) alloy corrosion and mechanical properties to support the accurate prediction of alloy performance using CNN models. By incorporating DFT calculations, the project will gain deeper insights into the corrosion and mechanical behaviours of Mg alloys, further enhancing the prediction accuracy of the CNN models. Ultimately, the optimized alloys will be combined with pH-responsive materials to achieve intelligent degradation control, ensuring the degradation rate aligns with the bodys healing process. Through this innovation, Mg alloys are expected to see a 30-40% improvement in corrosion resistance, a 50% reduction in experimental time, and a significant decrease in harmful waste production. The DREAM project will play a crucial role in the advancement of green medical technologies while driving innovation in biomedical materials.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences databases
- medical and health sciences clinical medicine surgery
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- medical and health sciences medical biotechnology implants
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
SO17 1BJ SOUTHAMPTON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.