Objective
The study of intrinsically disordered proteins (IDPs) in cellular environments is complicated by their complex structures and dynamics, leading to challenges in understanding the role of topology in crowded media. Single-chain nanoparticles (SCNPs) have emerged as simplified synthetic models of IDPs, allowing researchers to explore structural and dynamical behaviors without the interference of molecular interactions. Recent advancements in SCNP synthesis methods for biopolymers and polyelectrolytes present new opportunities to study topological effects in complex phases such as polyelectrolyte complex (PEC) coacervates, which are vital for understanding phase separation in intracellular membraneless organelles. The objective of this research is to use model polypeptide SCNPs to elucidate the effects of their topology on the structure and dynamics of PEC coacervates. We hypothesize that the self-coiled structures of SCNPs influence the stoichiometric distribution of polyion charges, thereby affecting the phase behavior and dynamics of PEC coacervates. Our specific aims include: (1) the synthesis and characterization of polyelectrolyte SCNPs with varying morphologies, (2) investigating the impact of SCNP topology on the local structure of PEC coacervates, and (3) exploring dynamic signatures associated with topologically distinct coacervate structures. Utilizing state-of-the-art techniques such as small-angle neutron scattering, wide-angle X-ray scattering, and neutron spin echo, this project aims to advance our understanding of the topological effects in coacervation and contribute to the broader knowledge of phase behavior in both synthetic and biological systems.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences mathematics pure mathematics topology
- natural sciences biological sciences biochemistry biomolecules proteins
- engineering and technology nanotechnology nano-materials
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
20018 DONOSTIA - SAN SEBASTIAN
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.