Objective
One of the top ten tumors that occurs worldwide most commonly is renal cell carcinoma (RCC) and its incidence is increasing. Regulatory T cells (Tregs), expressing transcription factor FOXP3, play a critical role in the suppression of inflammatory responses maintenance of self-tolerance. However, within the TME, Tregs contribute to tumor development and progression by reducing antitumor immune responses and promoting tumor growth. The dysregulation of specific lncRNAs has been correlated with the prognostic outcomes of patients with RCC, whereas the lncRNA dysregylation in tumor infiltrating lymphocytes is unclear. The overall objective of REGULINC is to increase our understanding of the role of both known and novel lincRNAs in governing the function of regulatory T cells (Tregs) present in the tumor microenvironment (TME) of RCC. This study will identify for the first time the TILs-specific lincRNAs with a focus on Tregs, and their role in Treg interactions with other immune cells in RCC samples. REGULINC will probe into the role of novel lincRNAs in the stability of Tregs and their cell-suppressive capacity, and ascertain if modulation of selected lincRNAs could result in enhanced immune response by TILs in the TME. The project will gain new mechanistic understanding of how lincRNA network defines Tregs activity in TME of RCC. It will also develop novel tools for therapeutic intervention through specifically targeting immune-suppressive Tregs to boost immune response in the TME of RCC.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
20014 Turku
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.