Objective
Stroke is a leading and increasingly important cause of death and disability in the EU. Yet, we have only few effective treatments and an unsatisfactory understanding of human stroke pathophysiology. Current diagnostic algorithms fail to capture pathophysiological mechanisms in daily clinical practice, hindering the allocation of patients to treatments and the development of novel therapies. While stroke care algorithms rely on clinical and single-timed imaging assessments, thousands of proteins and metabolites circulate within the blood representing a neglected window into our body. With MAP-STROKE, I aim to leverage serial multi-omics, longitudinal imaging, and deep clinical phenotyping data from the recently completed PROMISE study (N>500) to create a molecular map of human ischemic stroke and to identify novel clinically meaningful molecular biomarkers. By combining multiple unique project features including i) a novel molecular conceptualization of stroke, ii) the integration of genomic, proteomic and metabolomic data, iii) high-frequency serial assessments, iv) longitudinal imaging and phenotyping, and v) novel bioinformatics methodology including multi-omic factor analysis, MAP-STROKE goes considerably beyond the current state-of-the art and will advance personalized medicine in stroke. The MSCA fellowship under the mentorship of Dr. Steffen Tiedt at the Institute for Stroke and Dementia Research at LMU Munich would give me the exceptional opportunity to apply and expand my bioinformatics expertise in molecular modeling towards more complex multimodal biomedical data and to develop the skillset needed to become an expert and eventually independent group leader in medical bioinformatics in Europe. I envision the identified molecular biomarkers to drive precision medicine in stroke and to reduce its societal and economical burden.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine physiology pathophysiology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine neurology dementia
- medical and health sciences basic medicine neurology stroke
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.