Project description
Mitochondria transfer and T cell immunity
Recent evidence indicates that mitochondria, the cellular organelles responsible for energy production, can be transferred between cells through various mechanisms. This newly discovered process seems to influence the function of cells, and considering the role of mitochondria in immune responses, it may have ramifications for immunity. With the support of the Marie Skłodowska-Curie Actions programme, the MitoTransferImmunity project will investigate how mitochondria transferred from bone marrow stromal cells may affect T cell function. Researchers will focus on reactive oxygen species production and adaptive immune responses. By exploring this novel communication pathway, the study could uncover mechanisms that shape immune activation or suppression.
Objective
Mitochondria are organelles (‘little organs’) of the cell that generate the majority of its energy and have been shown to play a key role in host immunity. Recent evidence has demonstrated that mitochondria within a cell are not fixed, but are capable of transferring from one cell to another through a process known as ‘mitochondrial transfer’. My project focus on the transfer of mitochondria from bone marrow stromal cells (BMSCs) to immune T cells. The objectives of the project are to explore the effect of BMSC mitochondrial transfer cells on (i) immune T cell functionality (in particular ROS production) and (ii) its role in adaptive immune cell responses. The MSCA fellowship and tailored training program will help me towards my career goal of establishing my own junior research group by increasing my academic track record, helping me gain critical supervisory/teaching experience, and expand my technical/transferrable skill sets.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.