Project description
Pharmacological prevention of life-threatening brain haemorrhage
Approximately 15 million people in the EU have a distended bulge in a blood vessel in their brain. If this intracranial aneurysm (IA) bursts, the patient experiences life-threatening bleeding in the space between the brain and skull (subarachnoid haemorrhage or SAH). Treatment is complicated and invasive, seeking to remove excess blood and relieve pressure, stop the bleeding, and repair the IA. Clot formation mediated by activated platelets is a common feature of ruptured and unruptured IAs. Based on their data suggesting that a platelet receptor plays a critical role in rupture, the ERC-funded INTERRUPT project aims to investigate whether pharmacological inhibition of this platelet receptor can prevent IA rupture via experimental models.
Objective
In the European Union, an estimated 15 million individuals harbour unruptured intracranial aneurysms (IAs), each at constant risk of rupture and subsequent subarachnoid haemorrhage (SAH). The imminent threat of IA rupture remains a significant clinical challenge, further exacerbated by the absence of safe and efficacious non-invasive treatments, mainly due to gaps in understanding the underlying mechanisms. Notably, intrasaccular clot formation is a prevalent feature of both ruptured and unruptured IAs, with activated platelets facilitating leukocyte recruitment. We hypothesize that platelets play a pivotal role in the development and rupture of IAs. We have identified a platelet receptor as a critical factor in IA rupture, based on compelling data from a preclinical mouse model.
The goal of our ERC-POC project is to investigate and establish pharmacological inhibition of this platelet receptor as a groundbreaking therapeutic strategy for preventing IA rupture. To achieve this, we have designed a comprehensive, interdisciplinary approach encompassing a preclinical model and computational fluid dynamics applied to 3D aneurysm-like vessels. Our objectives are to validate the efficacy of inhibiting this platelet receptor in preventing IA rupture in mice and to thoroughly examine the impact of a receptor inhibitor on platelet function under dynamic conditions that mimic aneurysmal environments. Ultimately, our project aims to establish the clinical proof of targeting this platelet receptor with a leading compound to prevent IA rupture and significantly reduce the risk of SAH. By doing so, we aspire to alleviate the societal burden of intracranial aneurysms, offering a pioneering therapeutic framework for the management of unruptured IA.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2024-POC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.