Project description
A new immune approach to chronic inflammation
Many chronic inflammatory diseases, such as rheumatoid arthritis and spondyloarthropathies, are currently managed with medications that suppress the immune system. The mainstay of treatment is immunosuppressive therapy. But this comes with downsides, including increased susceptibility to infections and limited long-term relief. With this in mind, the ERC-funded ILCE project explores a new curative treatment approach involving innate lymphoid cells (ILCs), a type of immune cell involved in inflammation. Specifically, it will develop an ILC engager that can precisely target and reprogramme the immune response to resolve inflammation naturally.
Objective
Chronic inflammatory diseases, such as rheumatoid arthritis (RA) and spondyloarthropathies (SpA) represent a persistent healthcare challenge, requiring life-long management because of treatments with limited long-term efficacy. The key to a breakthrough may lie in the strategic engagement of Innate Lymphoid Cells (ILCs), whose potential in resolving inflammation and reprogramming tissue memory emerges from the recent ERC-funded research by Rauber et al. (2024). The study published in Nature Immunology elucidates the physiological function of ILCs to control inflammation. Building on this, we propose an innovative ILC engager (ILCE), aiming to harness natural pathways of resolution of inflammation and to offer a significant improvement over anti-cytokine therapies. Our approach bypasses generalized immunosuppression and thereby reduces the risk of infection by maintaining the body's acute inflammatory response. The development of an ILCE holds the promise to gain a new class of precise and efficacious therapeutics for chronic inflammatory diseases, revolutionizing patient outcomes by tailoring treatments to the nuanced pathophysiology of inflammation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine rheumatology
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences basic medicine immunology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2024-POC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
91054 Erlangen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.