Project description
3D tissue scanner for cancer diagnosis
Histopathology, the gold standard for cancer diagnosis, relies on 2D tissue slices, which can limit accuracy and, in some cases, influence treatment decisions. Although volumetric tissue analysis offers clear advantages, the field remains largely dependent on traditional 2D methods. Light-sheet fluorescence microscopy (LSFM) shows great potential for 3D imaging, but its broader application has been held back by technical challenges. In this context, the EIC-funded 3DPATH project will leverage key innovations in LSFM and data analysis developed in earlier research efforts to build a 3D tissue scanner suitable for clinical use. The aim is to enable more accurate diagnoses and significantly improve patient care. It also promises to position Europe as a leader in next-generation diagnostic technologies.
Objective
Histopathology is a century-old standard for the diagnosis of cancer and other diseases, and for the choice of personalized treatments. Despite its paramount importance for clinical practice, this method is still limited to the analysis of thin slices, presenting a 2D view of the intrinsically 3D structure of biological tissue. Current histopathology practice poses the risk of severely undersampling relevant tissue features: indeed, a growing amount of data demonstrates that traditional 2D analysis produces inconsistent and unreliable results that may have important implications in treatment choice and other clinical decisions.
Despite the compelling evidence of the clinical benefits of volumetric tissue analysis, clinical practice is still anchored to 2D imaging. A transition towards 3D inspection would be a quantum leap in the histopathology field but has been prevented hitherto because of technical limitations. Indeed, light-sheet fluorescence microscopy (LSFM) has been hailed in the last decades as a game changer in the field. However, LSFM-based solutions have profound limitations in terms of throughput, reliability and scalability that prevent their use outside specialised research labs.
In 3DPATH, we want to leverage several key innovations in LSFM and data analysis technology – developed in previous research projects – to develop a 3D tissue scanner suitable for clinical use. The success of this project will revolutionize histopathology leading to more accurate diagnosis, improving quality of care for patients all over the world, and bringing Europe at the forefront of diagnostic technologies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences data science
- natural sciences physical sciences optics microscopy
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pathology
- engineering and technology medical engineering medical laboratory technology diagnostic technologies
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2024-TRANSITION-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
50019 SESTO FIORENTINO
Italy
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.