Project description
Safer manufacturing protocols for therapeutic proteins
N-glycosylation is a cellular process that naturally adds sugar molecules (N-glycans) to proteins after synthesis. N-glycans impact protein stability and interactions, and are involved in cell signalling and recognition as well as in immune processes such as antibody-dependent cellular cytotoxicity. It is for this reason that many biological drugs, including monoclonal antibodies, rely on N-glycans for activity, safety and efficacy. However, current biological manufacturing methods generate highly heterogeneous N-glycan patterns, which makes manufacturing and regulatory approval more difficult because of variability. The EIC-funded GlycoBoost project proposes to develop a precision cell engineering platform that adds homogeneous N-glycans to therapeutic proteins. The project is expected to unlock the full potential of monoclonal antibodies and lead to safer and more effective therapies.
Objective
Biologics comprise a $511B market of advanced therapeutics that are used to treat cancer, autoimmune diseases, infectious diseases and beyond. Two thirds of biologics are decorated with sugar molecules attached to the therapeutics, including all antibody therapeutics, called monoclonal antibodies (mAbs). These sugar molecules are known as N-glycans and are vitally important for therapeutic safety and efficacy. To date, the N-glycans are poorly controlled and, as such, display highly heterogeneous patterns on a therapeutic. This complicates large-scale production and regulatory approval of biologics, and significantly limits the possibility of using N-glycans in therapeutic design. GlycoBoost revolutionises mAb design by delivering consistent N-glycans, precisely profiled with advanced analytical techniques. This innovation unlocks the full potential of N-glycans to elevate the effectiveness of mAbs.
Kyron.bio’s breakthrough technology uses cell engineering to produce therapeutic proteins with uniform and precision-controlled N-glycan patterns. This technology is being used to produce glycoengineered mAbs that are safer and more effective for patients, starting with mAbs used to treat autoimmune diseases where patient resistance to current treatments remains high.
Through a well-established collaboration between kyron.bio and Genos, one of the world leaders in glycoanalytics on whose SYSCID project this proposal is built, GlycoBoost aims to advance the project to commercialisation through the development of advanced glycoanalytical techniques, preclinical evaluation, pre-industrialisation, bespoke customer PoC’s, partnership-building, and fundraising. GlycoBoost will place Europe at the heart of the glycobiology revolution, leading to the development of safer and more effective treatments for autoimmune diseases and ultimately redefining the landscape of therapeutic drug development.
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
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Call for proposal
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(opens in new window) HORIZON-EIC-2024-TRANSITION-01
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75008 Paris
France
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