Objective
NanoPhoria bioscience leads the way in the development of groundbreaking inhalable cardiovascular treatments by combining innovative biologic drugs with a unique nanoparticle-mediated delivery platform.
We seek EIC support to develop our lead product NP-MP1. This highly innovative lung-to-heart nano-in-micro peptide formulation has the potential to radically improve the treatment of Heart Failure with reduced Ejection Fraction (HFrEF), a chronic and largely unmet clinical condition affecting millions worldwide, with mortality and morbidity higher than most cancers.
The peptide has proven safe and effective in restoring contractility in diseased cardiomyocytes, the cells responsible for heart to pumping. It modulates the L-type Calcium Channel, a key molecular player in excitation-contraction coupling, leading to the recovery of ejection fraction and halting HFrEF progression. Thanks to the patient-friendly inhalable formulation and the nano-carriers, the peptide can selectively and non-invasively reach the cardiomyocytes and perform its pharmacological action.
Supported by solid proofs of concept in clinically relevant animal models, NP-MP1 offers a disease modifying mechanism of action and a targeted heart delivery, minimising accumulation in other organs and associated side effects: an approach not yet exploited in any clinical cardiovascular strategy. Therefore, NanoPhoria's solution is set to significantly improve life expectancy, quality of life and cost-effectiveness, outperforming competitors.
The EIC project aims to further de-risk NP-MP1's development process, complete First-in-Human clinical trials and attract potential licensees/acquirers, bridging the gap between the current validation stage and the future exit.
NanoPhoria's experienced team, collaboration with renowned academic institutions, CROs and CMOs, and established affiliations with distinguished cardiologists guarantee a successful pathway to clinical validation and commercial triumph.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors optical sensors
- natural sciences biological sciences biochemistry biomolecules
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC-ACC - HORIZON EIC Accelerator
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2024-ACCELERATOR-02
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
20122 MILAN
Italy
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.