Project description
Revealing the hidden networks behind episodic memory
The hippocampus, entorhinal cortex, and broader brain networks are all working together to build episodic memory. What is not certain are aspects of the entorhinal cortex’s functional organisation. The ERC-funded ENTONET project will explore the overlooked anatomical and functional properties of this critical brain region. It will combine precision neuroimaging, advanced MRI techniques, computational modelling, and comparative animal anatomy to shed light on the human entorhinal cortex across the lifespan. Specifically, the project will investigate how entorhinal networks support memory processes and how they develop and change over time. The findings will benefit clinical research and the study of memory-related disorders. Overall, ENTONET’s goal is to establish new frameworks for understanding the neural basis of episodic memory.
Objective
Episodic memory critically depends on the brain regions located in the medial temporal lobe. Anatomical studies in rodents and monkeys that studied the interactions between the hippocampus, the entorhinal cortex and the rest of the brain, positioned the entorhinal cortex as a key region mediating almost all interactions between the hippocampus and the rest of the brain. These anatomical studies were the provenance of a mechanistic model of episodic memory - the dual stream model. Over the last two decades, this model has become the most influential neuroanatomical and neurocognitive paradigm for studying episodic memory in human and non-human animals. However, recent human data suggest that critical anatomical properties of the entorhinal cortex were overlooked in prior research, inviting a reformulation of entorhinal cortex’s functional properties.
Building on these findings, ENTONET will leverage precision neuroimaging, advanced MRI tools, computational modeling and animal anatomy to make a major breakthrough in our understanding of the functional properties of the human entorhinal cortex. To this end, ENTONET will comprise four work packages with the objective to study the human entorhinal cortex using fMRI across the human life-span.
Using novel and unconventional experimental approaches, ENTONET will make dramatic contributions to developmental and clinical fields, and open new research horizons in the field of neuroscience of memory.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
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Call for proposal
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(opens in new window) ERC-2025-STG
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7491 Trondheim
Norway
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