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The organizational principles of human entorhinal cortex and their contributions to episodic memory

Objective

Episodic memory critically depends on the brain regions located in the medial temporal lobe. Anatomical studies in rodents and monkeys that studied the interactions between the hippocampus, the entorhinal cortex and the rest of the brain, positioned the entorhinal cortex as a key region mediating almost all interactions between the hippocampus and the rest of the brain. These anatomical studies were the provenance of a mechanistic model of episodic memory - the dual stream model. Over the last two decades, this model has become the most influential neuroanatomical and neurocognitive paradigm for studying episodic memory in human and non-human animals. However, recent human data suggest that critical anatomical properties of the entorhinal cortex were overlooked in prior research, inviting a reformulation of entorhinal cortex’s functional properties.
Building on these findings, ENTONET will leverage precision neuroimaging, advanced MRI tools, computational modeling and animal anatomy to make a major breakthrough in our understanding of the functional properties of the human entorhinal cortex. To this end, ENTONET will comprise four work packages with the objective to study the human entorhinal cortex using fMRI across the human life-span.
Using novel and unconventional experimental approaches, ENTONET will make dramatic contributions to developmental and clinical fields, and open new research horizons in the field of neuroscience of memory.

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Programme(s)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-ERC - HORIZON ERC Grants

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) ERC-2025-STG

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Host institution

NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 638 181,88
Address
HOGSKOLERINGEN 1
7491 TRONDHEIM
Norway

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Region
Norge Trøndelag Trøndelag
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 638 181,88

Beneficiaries (2)

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