Objective
A “gut feeling” is an intuition arising without conscious reasoning. This idiom reflects a profound biological truth: the gut is directly connected to subcortical systems that regulate arousal, mood, and behavior. However, brain-body theories often overlook these connections and their influence on arousal, a key mechanism through which the gut affects cognition. Moreover, we lack a detailed understanding of how different time scales of gut activity -from rapid contractions (seconds to minutes) to slower hormonal fluctuations (minutes to hours)- interact with brain dynamics, mood, and cognition. Critically, this gap also extends to mental health, where gut signals are increasingly recognized for their crucial role, yet a comprehensive mechanistic framework linking specific symptoms to altered brain-gut interactions remains absent.
GUT-FEEL will address these challenges by systematically investigating gut-brain interactions across the vigilance, affective, and physiological dimensions of arousal, using pharmacological manipulations of the gut and brain. By combining non-invasive measurements of stomach activity with a dense, hourly sampling of gut hormones, I will probe how fast and slow gut signals interact with brain activity, captured simultaneously through electroencephalography and functional magnetic resonance imaging. This novel approach will allow me to untangle the complex web of interactions between the gut and the brain, both in healthy individuals and in those with depression.
By positioning the gut as a critical modulator of brain function, GUT-FEEL will reshape our understanding of the intricate links between the brain, body, and mind. This groundbreaking approach will push the boundaries of cognitive neuroscience and pave the way for gut-focused therapeutic interventions, revolutionizing how we understand and treat mental health conditions such as depression. In doing so, GUT-FEEL is set to redefine the future of brain-body research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-STG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
14558 Nuthetal
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.