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Mapping the Uncharted Human Metabolism for Novel Food Bioactives

Objective

BioTransform is a multidisciplinary doctoral network aiming to investigate the role of certain constituents found in food products (food bioactives - FB) on human health, focusing on their metabolism. FB coexist with nutrients, but they are biologically active compounds present in our diet and characterised by great structural variability and biological properties. Despite the imperative role of gut microbiota in health maintenance and disease prevention, the available information regarding FB metabolism remains scarce and the biotransformation occurring in the human organism highly unexplored. Thus, the goal of BioTransform is to combine state-of-the-art methods, technologies and approaches in a complementary and integrated way to reveal the impact of FB and their metabolites (biotransformation products) on health and disease. To this end, human pilot studies, in vitro and in silico metabolism simulation methods, gut microbiota sequencing, metabolite profiling and metabolomics will be employed. Metabolites will be biologically profiled through biochemical and cell-based assays. In BioTransform, the metabolism of olive and bilberry FB (secoiridoids, phenols and polyphenols), which are European flagship food products with proven activity in metabolism-related pathologies, will be systematically investigated. A key innovative characteristic of BioTransform is the holistic approach towards metabolism of FB, unique so far, combining all required disciplines and including experts at EU level. BioTransform objectives will be accomplished through eleven complementary doctoral projects from nine education and research entities, additionally including the participation of six associated partners from the private sector and one from academia. Beyond the scientific achievements, the ultimate goal of BioTransform is to educate, train and prepare young scientists to be interdisciplinary and competent researchers and professionals in the area of health and food science.

Fields of science (EuroSciVoc)

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) HORIZON-MSCA-2024-DN-01

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Coordinator

UNIVERSITEIT ANTWERPEN
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 577 080,00
Address
PRINSSTRAAT 13
2000 Antwerpen
Belgium

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Region
Vlaams Gewest Prov. Antwerpen Arr. Antwerpen
Activity type
Higher or Secondary Education Establishments
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data

Participants (8)

Partners (7)

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