Project description
Training in glyconanotechnology to fill gaps in cancer immunotherapy
Cancer immunotherapy is a rapidly advancing therapeutic approach, with vaccine prototypes in phase III trials. However, guidelines to select the optimal format (mRNA vs peptide) in vaccine formulations are urgently needed for clinical translation. Glyconanomaterials can address this challenging task providing the precision delivery antigens to antigen-presenting cells (APC) and boosting APC activation. With the support of the Marie Skłodowska-Curie Actions programme, the CanGoNano project will explore glyconanotechnology to shed light on the molecular mechanisms of immune system activation, leading one step closer to the development of cancer vaccines. It will train doctoral candidates in the synergistic potential of glycoscience and nanotechnology to fill knowledge gaps in cancer immunotherapy, equipping them with valuable skills for careers in academia and industry.
Objective
Immunotherapy is at the frontier of cancer treatment, with vaccine prototypes in phase III clinical trials. However, guidelines for the selection of the optimal antigen format (mRNA vs peptide) to be used in vaccine formulations are still not available. The glycoscience-oriented CanGoNano DN has identified this gap and proposes for the first time a research & training & innovation action that aims to unveil the molecular mechanisms of immune system activation at the molecular level. Our innovative DN puts antigen presenting cells (APC) as the immune system hub to move forward on the rational selection of antigen formats towards next generation of cancer vaccines. Glyconanomaterials are precision tools for the controlled delivery of antigens to APC and will shed light on molecular mechanisms that rule APC activation according to antigen format. CanGoNano credibility and high quality are ensured by a partnership of experts in glycoscience & nanotechnology & immunology. 12 Academics, 6 SMEs & 1 clinical Institution encompass complementary & intersectoral expertise, and unique tools to train 14 doctoral candidates (DC). The combination of interdisciplinary & excellent science, industry know-how and clinical perspective will cover the entire process from fundamental insights to innovative solutions. CanGoNano will create a critical mass of uniquely skilled researchers in glyconanotechnology. We will train DC on the synergic potential of glycoscience & nanotech to provide the missing knowledge in cancer immunotherapy, and will equip DC with transferrable skills to be in an advantageous position for job opportunities in academia and industry. Deciphering the key interactions in APC activation expands the frontiers of knowledge and enables addressing key challenges in cancer immunotherapy. CanGoNano will strengthen the EU innovation capacity bringing new fundamental knowledge for the future development of precision anticancer vaccines to market and policy stakeholders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- engineering and technology nanotechnology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine immunology immunotherapy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-DN-01
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50121 Florence
Italy
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Participants (10)
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1045 Budapest
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
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75794 PARIS
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5349 AB Oss
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20122 Milano
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20009 San Sebastian
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1190 WIEN
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1099 085 Lisboa
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1081 HV Amsterdam
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37135 VERONA
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26006 LOGRONO
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Partners (11)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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1040 BRUXELLES
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A94N447 DUBLIN
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20121 Milano
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5046 Warradale
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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1053 BUDAPEST
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48940 LEIOA
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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6525 GA NIJMEGEN
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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28049 MADRID
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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1180 Wien
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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67081 STRASBOURG
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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1081 HV Amsterdam
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.